| Diastolic dysfunction in arterial hypertension. | |
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MedLine Citation:
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PMID: 11416678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Left ventricular diastolic properties are important markers of pump function and are frequently abnormal when myocardial insults alter tissue structure. Alterations can be limited to the early diastolic phase (early active relaxation) or to late diastolic filling (late ventricular compliance), but more often involve regulation of both phases of diastole. In asymptomatic patients with arterial hypertension, left ventricular relaxation is often prolonged, independently, at least in part, of cardiac loading conditions and left ventricular geometry, but this abnormality is associated with early signs of systolic dysfunction. Uncontrolled hypertension, diabetes, and obesity are most often associated with ischemic heart disease and impaired diastolic function. Reducing blood pressure with antihypertension therapy will reduce myocardial afterload, regress LVH, and improve systolic and diastolic function. In patients with symptoms of CHF with a normal ejection fraction, however, changes in therapy may be indicated. Greater emphasis should be placed on using medications that decrease myocardial load, but also reduce the effects of neurohormonal activation. (c)2001 by Le Jacq Communications, Inc. |
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Authors:
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G de Simone; V Palmieri |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 3 ISSN: 1524-6175 ISO Abbreviation: J Clin Hypertens (Greenwich) Publication Date: 2001 Jan-Feb |
Date Detail:
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Created Date: 2001-06-25 Completed Date: 2001-08-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: United States |
Other Details:
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Languages: eng Pagination: 22-7 Citation Subset: IM |
Affiliation:
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Department of Clinical and Experimental Medicine, Federico II University Hospital, School of Medicine, v. S. Pansini 5-80131, Naples, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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therapeutic use Diabetes Complications Diastole / physiology* Heart Failure / physiopathology*, prevention & control Humans Hypertension / complications*, drug therapy, physiopathology* Myocardial Ischemia / physiopathology, prevention & control Obesity / complications Systole / physiology Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
| Comments/Corrections | |
Comment In:
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J Clin Hypertens (Greenwich). 2001 Jan-Feb;3(1):14-5
[PMID:
11416676
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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