Document Detail

Diastolic dysfunction as a link between hypertension and heart failure.
MedLine Citation:
PMID:  19427497     Owner:  NLM     Status:  MEDLINE    
LVDD as an early measure of myocardial end-organ damage is commonly associated with hypertension and may well precede development of LVH in hypertension. About half of the patients presenting with heart failure have a normal ejection fraction, a clinical syndrome that is commonly referred to as HFPEF or diastolic heart failure and is commonly associated with impaired LV relaxation and increased diastolic stiffness. DD and HFPEF are commonly associated with advancing age and hypertension and increase in prevalence in association with these conditions, but there is a paucity of data on any specific therapeutic regimen. Hypertension control appears to be the most effective strategy in improving diastolic function and possibly for reducing the morbidity and mortality associated with HFPEF.
Anil Verma; Scott D Solomon
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Medical clinics of North America     Volume:  93     ISSN:  1557-9859     ISO Abbreviation:  Med. Clin. North Am.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-11     Completed Date:  2009-06-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985236R     Medline TA:  Med Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  647-64     Citation Subset:  AIM; IM    
Ochsner Clinic Foundation, New Orleans, LA 70121, USA.
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MeSH Terms
Endothelium / physiopathology
Extracellular Matrix / metabolism
Heart Failure, Diastolic / drug therapy,  physiopathology*
Hypertension / complications,  drug therapy,  physiopathology*
Hypertrophy, Left Ventricular / drug therapy,  etiology,  physiopathology*
Muscle Cells / metabolism
Stroke Volume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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