| Diastolic coronary resistance and capacitance are independent of the duration of diastole. | |
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MedLine Citation:
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PMID: 2000989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Systolic myocardial contraction may produce changes in coronary resistance and capacitance that persist throughout a normal diastole. In addition, coronary resistance and capacitance as determined in the arrested heart may not accurately describe normal diastolic behavior. To evaluate these possibilities, an identification method capable of characterizing the input impedance of the coronary circulation in as little as 150 ms was developed. Using this method, coronary dynamics were measured during early and late diastoles in the beating heart with tone intact as well as during adenosine-induced maximal vasodilation. Coronary dynamics were also measured in the arrested heart during maximal vasodilation. With vasomotor tone intact, the parameters of a lumped model of the coronary circulation showed no variation from early to late diastole. During maximal vasodilation, model parameters also showed no variation from early to late diastole. Parameters in the arrested heart were not statistically different from those of the beating heart during maximal vasodilation. However, model parameters determined during maximal vasodilation were significantly different from those determined with tone intact. These results suggest that although coronary resistance and capacitance are dependent on vasomotor tone, they remain constant throughout diastole and remain similar in the arrested heart. |
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Authors:
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R M Judd; D A Redberg; R E Mates |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 260 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1991 Mar |
Date Detail:
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Created Date: 1991-04-11 Completed Date: 1991-04-11 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H943-52 Citation Subset: IM |
Affiliation:
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Department of Mechanical and Aerospace Engineering, State University of New York, Buffalo 14260. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Coronary Circulation Coronary Vessels / physiology* Diastole* Dogs Female Male Models, Cardiovascular Time Factors Vascular Resistance* Vasodilation |
| Grant Support | |
ID/Acronym/Agency:
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1-KO8-HLB-01168/HL/NHLBI NIH HHS; 2-PO1-HLB-15194/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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