Document Detail


Diastereoselective hydrophosphonylation of imines using (R,R)-TADDOL phosphite. Asymmetric synthesis of alpha-aminophosphonic acid derivatives.
MedLine Citation:
PMID:  20672154     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Efficient synthesis of alpha-aminophosphonic acid derivatives is achieved, the key step being a diastereoselective hydrophosphonylation of N-diphenylphosphinyl imines using a readily available chiral cyclic (R,R)-TADDOL-phosphite derived from inexpensive natural tartaric acid.
Authors:
Francisco Palacios; Tomasz K Olszewski; Javier Vicario
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-29
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  8     ISSN:  1477-0539     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-08     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  4255-8     Citation Subset:  IM    
Affiliation:
Departamento de Química Orgánica I, Facultad de Farmacia, Universidad del País Vasco, Apartado 450, 01080 Vitoria, Spain. francisco.palacios@ehu.es
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MeSH Terms
Descriptor/Qualifier:
Imines / chemical synthesis,  chemistry*
Molecular Structure
Phosphites / chemical synthesis,  chemistry*
Phosphonic Acids / chemical synthesis*,  chemistry
Stereoisomerism
Tartrates / chemical synthesis,  chemistry
Chemical
Reg. No./Substance:
0/Imines; 0/Phosphites; 0/Phosphonic Acids; 0/Tartrates; 526-83-0/tartaric acid

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