Document Detail


Diastereomeric Resolution of Racemic o-Chloromandelic Acid.
MedLine Citation:
PMID:  22730179     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The separation of rac-o-chloromandelic acid 1 with enantiopure aryloxypropylamine via diastereomeric salt formation was investigated. (R)-o-chloromandelic acid (R)-1, a key intermediate for the antithrombotic agent clopidogrel, was obtained in 65% yield and 98% ee by Dutch resolution of rac-1 with (S)-2-hydroxyl-3-(p-chlorophenoxy) propylamine (S)-5 as resolving agent and (S)-2-hydroxyl-3-(o-nitrophenoxy) propylamine (S)-4 as nucleation inhibitor. Chirality, 2012. © 2012 Wiley Periodicals, Inc.
Authors:
Pei Wang; En Zhang; Peng Zhao; Qing-Hua Ren; Yuan-Yuan Guan; Hong-Min Liu
Related Documents :
21662939 - Migration and diffusion coupled with a fast preceding reaction. voltammetry at a microe...
17470369 - Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats.
10086989 - Anti-herpes simplex virus activity of moronic acid purified from rhus javanica in vitro...
17017909 - In utero exposure to phthalates and fetal development.
708999 - Inhibition by n-acetyl neuraminic acid of platelet thrombogenesis induced by laser inju...
17336429 - Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents.
12500789 - Mechanical characteristics of an absorbable copolymer internal fixation pin.
12713419 - New acetylenic acids from a sponge of the genus stelletta.
8982339 - Exophilin a, a new antibiotic from a marine microorganism exophiala pisciphila.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-22
Journal Detail:
Title:  Chirality     Volume:  -     ISSN:  1520-636X     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8914261     Medline TA:  Chirality     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
School of Pharmaceutical Sciences and New Drug Research & Development Center, Zhengzhou University, Zhengzhou, People's Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Quantitative measurement of the magnetic moment of individual magnetic nanoparticles by magnetic for...
Next Document:  Detection of endogenous iron deposits in the injured mouse spinal cord through high-resolution ex vi...