Document Detail

Diastereomeric Resolution of Racemic o-Chloromandelic Acid.
MedLine Citation:
PMID:  22730179     Owner:  NLM     Status:  Publisher    
The separation of rac-o-chloromandelic acid 1 with enantiopure aryloxypropylamine via diastereomeric salt formation was investigated. (R)-o-chloromandelic acid (R)-1, a key intermediate for the antithrombotic agent clopidogrel, was obtained in 65% yield and 98% ee by Dutch resolution of rac-1 with (S)-2-hydroxyl-3-(p-chlorophenoxy) propylamine (S)-5 as resolving agent and (S)-2-hydroxyl-3-(o-nitrophenoxy) propylamine (S)-4 as nucleation inhibitor. Chirality, 2012. © 2012 Wiley Periodicals, Inc.
Pei Wang; En Zhang; Peng Zhao; Qing-Hua Ren; Yuan-Yuan Guan; Hong-Min Liu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-22
Journal Detail:
Title:  Chirality     Volume:  -     ISSN:  1520-636X     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8914261     Medline TA:  Chirality     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
School of Pharmaceutical Sciences and New Drug Research & Development Center, Zhengzhou University, Zhengzhou, People's Republic of China.
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