| Diarylcyclopentendione metabolite obtained from a Preussia typharum isolate procured using an unconventional cultivation approach. | |
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MedLine Citation:
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PMID: 23046341 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An uncommon 2,5-diarylcyclopentenone compound, preussidone (1), and a new biphenyl compound, 1',5-dimethoxy-3,5'-dimethyl-2,3'-oxybiphenyl-1,2'-diol (4), together with two known biphenyl compounds, 5-methoxy-3,5'-dimethyl-2,3'-oxybiphenyl-1,1',2'-triol (2) and cyperin (3), were obtained from a Preussia typharum isolate that was procured using a panel of unconventional media formulations. The structures of the new compounds were established by NMR and mass spectrometry, while the absolute configuration of 1 was assigned by quantum chemical ECD and VCD calculations. The antimicrobial and DPPH radical scavenging activities of 1-4 were tested. Compounds 2 and 4 exhibited DPPH radical scavenging activities that were comparable to the positive control ascorbic acid. |
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Authors:
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Lin Du; Jarrod B King; Brian H Morrow; Jana K Shen; Andrew N Miller; Robert H Cichewicz |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-10-09 |
Journal Detail:
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Title: Journal of natural products Volume: 75 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-29 Completed Date: 2013-01-30 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 1819-23 Citation Subset: IM |
Affiliation:
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Institute for Natural Products Applications and Research Technologies, Stephenson Life Sciences Research Center, 101 Stephenson Parkway, University of Oklahoma, Norman, Oklahoma 73019-5251, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Ascomycota
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chemistry* Biphenyl Compounds / chemistry, isolation & purification*, pharmacology Cyclopentanes / chemistry, isolation & purification*, pharmacology Free Radical Scavengers / chemistry, isolation & purification*, pharmacology Molecular Structure Nuclear Magnetic Resonance, Biomolecular Picrates / chemistry, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI085161/AI/NIAID NIH HHS; R01 GM092219/GM/NIGMS NIH HHS; R01GM092219/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/1',5-dimethoxy-3,5'-dimethyl-2,3'-oxybiphenyl-1,2'-diol; 0/Biphenyl Compounds; 0/Cyclopentanes; 0/Free Radical Scavengers; 0/Picrates; 0/preussidone; 1898-66-4/2,2-diphenyl-1-picrylhydrazyl; 220W81TN3S/cyclopentanone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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