Document Detail


Diarylcyclopentendione metabolite obtained from a Preussia typharum isolate procured using an unconventional cultivation approach.
MedLine Citation:
PMID:  23046341     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An uncommon 2,5-diarylcyclopentenone compound, preussidone (1), and a new biphenyl compound, 1',5-dimethoxy-3,5'-dimethyl-2,3'-oxybiphenyl-1,2'-diol (4), together with two known biphenyl compounds, 5-methoxy-3,5'-dimethyl-2,3'-oxybiphenyl-1,1',2'-triol (2) and cyperin (3), were obtained from a Preussia typharum isolate that was procured using a panel of unconventional media formulations. The structures of the new compounds were established by NMR and mass spectrometry, while the absolute configuration of 1 was assigned by quantum chemical ECD and VCD calculations. The antimicrobial and DPPH radical scavenging activities of 1-4 were tested. Compounds 2 and 4 exhibited DPPH radical scavenging activities that were comparable to the positive control ascorbic acid.
Authors:
Lin Du; Jarrod B King; Brian H Morrow; Jana K Shen; Andrew N Miller; Robert H Cichewicz
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-09
Journal Detail:
Title:  Journal of natural products     Volume:  75     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-29     Completed Date:  2013-01-30     Revised Date:  2013-10-30    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1819-23     Citation Subset:  IM    
Affiliation:
Institute for Natural Products Applications and Research Technologies, Stephenson Life Sciences Research Center, 101 Stephenson Parkway, University of Oklahoma, Norman, Oklahoma 73019-5251, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Ascomycota / chemistry*
Biphenyl Compounds / chemistry,  isolation & purification*,  pharmacology
Cyclopentanes / chemistry,  isolation & purification*,  pharmacology
Free Radical Scavengers / chemistry,  isolation & purification*,  pharmacology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Picrates / chemistry,  pharmacology
Grant Support
ID/Acronym/Agency:
R01 AI085161/AI/NIAID NIH HHS; R01 GM092219/GM/NIGMS NIH HHS; R01GM092219/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/1',5-dimethoxy-3,5'-dimethyl-2,3'-oxybiphenyl-1,2'-diol; 0/Biphenyl Compounds; 0/Cyclopentanes; 0/Free Radical Scavengers; 0/Picrates; 0/preussidone; 1898-66-4/2,2-diphenyl-1-picrylhydrazyl; 220W81TN3S/cyclopentanone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Crystal structure of enterotoxigenic Escherichia coli colonization factor CS6 reveals a novel type o...
Next Document:  Is the Isolated Pentagon Rule Always Satisfied for Metallic Carbide Endohedral Fullerenes?