Document Detail

Diaphragmatic paralysis due to spinal muscular atrophy. An unrecognised cause of respiratory failure in infancy?
MedLine Citation:
PMID:  3977387     Owner:  NLM     Status:  MEDLINE    
An unusual form of spinal muscular atrophy presenting with respiratory failure was observed in four infants from two families. In one, whose death was attributed to pneumonia, the diagnosis was inferred retrospectively after two siblings died from an identical illness and were shown to have diaphragmatic paralysis and the typical electrophysiological and histological features of spinal muscular atrophy. Other signs of skeletal muscular weakness were absent or inconspicuous. The fourth, unrelated infant presented in an identical way but has survived for over a year on a ventilator. Two months after the onset of respiratory paralysis, more extensive skeletal muscular weakness was seen. Other infants, dying of unexplained respiratory illness, may have this disorder and some may be included in the miscellany of disorders that constitute the sudden infant death syndrome.
R C McWilliam; D Gardner-Medwin; D Doyle; J B Stephenson
Related Documents :
14566897 - Prevalence of osteophytes associated with the acromion and acromioclavicular joint.
3239577 - Prevalence of dominant mutations in spain: effect of changes in maternal age distribution.
11892037 - Prevalence and differential diagnosis of chronic rhinitis.
19540517 - Minimizing the risks of sudden infant death syndrome: to swaddle or not to swaddle?
7270517 - Spastic diplegia in premature infants. etiologic and diagnostic considerations.
1925697 - Infant mortality among ethnic immigrant groups.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  60     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1985 Feb 
Date Detail:
Created Date:  1985-04-04     Completed Date:  1985-04-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  145-9     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Infant, Newborn
Muscles / pathology
Muscular Atrophy / complications*,  pathology
Respiratory Paralysis / etiology*,  pathology
Spinal Cord / pathology
Sudden Infant Death / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Neonatal thyroid function: influence of perinatal factors.
Next Document:  Deaths in cots are not always cot deaths.