Document Detail

Diaphragmatic lymph vessel drainage of the peritoneal cavity.
MedLine Citation:
PMID:  1308679     Owner:  NLM     Status:  MEDLINE    
We have studied the drainage of peritoneal fluid through the diaphragmatic lymph vessels in sheep. To measure the lymphatic flow rate, we cannulated the lymphatic vessels and timed the flow from the cannula. After we infused Escherichia coli endotoxin into awake sheep, the diaphragmatic lymph flow rate increased substantially. However, we found no increase in lymph flow in anesthetized acutely operated sheep. This indicates that studies in anesthetized animals may yield underestimates of diaphragmatic lymph flow. In sheep, many of the diaphragmatic lymph vessels drain to the caudal mediastinal lymph node. We cannulated an efferent vessel from that node in 5 sheep. Several days later we infused 100 ml/kg of Ringer's solution into the abdominal space of each awake sheep. In response, the lymph flow rate increased from 0.15 +/- 0.16 ml/min (mean +/- SD) to 0.50 +/- 0.17 ml/min. Our results are important because they demonstrate that diaphragmatic lymph flow increases substantially after fluid infusions into the abdominal space.
R E Drake; J C Gabel
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood purification     Volume:  10     ISSN:  0253-5068     ISO Abbreviation:  Blood Purif.     Publication Date:  1992  
Date Detail:
Created Date:  1993-10-14     Completed Date:  1993-10-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8402040     Medline TA:  Blood Purif     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  132-5     Citation Subset:  IM    
Department of Anesthesiology, University of Texas Medical School, Houston 77030.
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MeSH Terms
Ascitic Fluid / metabolism*
Endotoxins / pharmacology
Escherichia coli
Infusions, Parenteral
Lymphatic System / metabolism*
Grant Support
Reg. No./Substance:
0/Endotoxins; 67924-63-4/endotoxin, Escherichia coli

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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