| Diaphragm pacing and noninvasive respiratory management of amyotrophic lateral sclerosis/motor neuron disease. | |
| | |
MedLine Citation:
|
PMID: 23042087 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Introduction: Although it is known that continuous noninvasive ventilation (CNIV) can prolong life in amyotrophic lateral sclerosis/motor neuron disease (ALS/MND), in this study we explore similar claims for diaphragm pacing (DP). Methods: NIV and DP users' vital capacities (VCs) over time and duration of NIV and CNIV dependence were analyzed for 354 non-DP and 8 DP ALS/MND patients. Results: Patients had a higher rate of monthly VC decline before NIV use (5.1 ± 7.6%) than during NIV use (2.5 ± 3.6%) (P < 0.01, 95% CI 0.84-4.5); the decline for 4 DP users was 3.7-20%. Fifty-five ALS/MND patients used part-time NIV for 19.9 ± 27.6 months until tracheostomy/death, whereas 113 others used it for 10.9 ± 10.5 months until CNIV dependence for another 12.8 ± 16.2 months. After placement, 7 DP users were CNIV dependent in 8.0 ± 7.0 months, whereas 6 underwent tracheostomy/died in 18.2 ± 13.7 months. Conclusions: CNIV prolonged the survival of 113 of the 354 non-DP and 6 DP ALS/MND patients by 12.8 and 10.2 months, respectively. DP provided no benefit on VC or mechanical ventilation-free survival. Muscle Nerve, 2012. |
| | |
Authors:
|
Kedar R Mahajan; John Robert Bach; Lou Saporito; Nick Perez |
Related Documents
:
|
7722727 - Orthognathic surgery versus orthodontic camouflage in the treatment of mandibular defic... 22772927 - The role of anemia in first simple febrile seizure in children aged 6 months to 5 years... 15961567 - The effects of early headgear treatment on dental arches and craniofacial morphology: a... 1998297 - Comparison of treatment effects with labial and lingual fixed appliances. 7044507 - Maquet osteotomy for chondromalacia patellae: avoiding the pitfalls. 2277567 - Comparison of lower concentrations of lidocaine to suppress bucking before extubation d... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-30 |
Journal Detail:
|
Title: Muscle & nerve Volume: - ISSN: 1097-4598 ISO Abbreviation: Muscle Nerve Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-10-8 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
|
Department of Physical Medicine and Rehabilitation, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, University Hospital B-403, 150 Bergen Street, Newark, New Jersey 07103, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Splitting of dihydrogen by five-membered zirconacycloallenoids: a novel pathway to conjugated diene ...
Next Document: Regeneration of articular cartilage by adipose tissue derived mesenchymal stem cells: Perspectives f...