| Diaper dermatitis: a therapeutic dilemma. Results of a double-blind placebo controlled trial of miconazole nitrate 0.25%. | |
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MedLine Citation:
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PMID: 11358560 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diaper dermatitis, an acute inflammation of the skin in the diaper area, is the most common dermatologic disorder of infancy. This placebo-controlled, randomized, double-blind, parallel-group trial compared the efficacy and safety of miconazole nitrate 0.25% in a zinc oxide/petrolatum base with that of the ointment base alone in treating acute diaper dermatitis in infants and evaluated the role of Candida albicans in the response to treatment. Infants age 2-13 months with diaper rash were treated with either miconazole nitrate 0.25% (N = 101) or ointment base (N = 101) for 7 days. Although improvement in rash from baseline was seen in both treatment groups on days 3, 5, and 7, patients receiving miconazole nitrate 0.25% had significantly fewer rash sites and lower mean total rash scores on days 5 and 7 (p < 0.001). In the miconazole nitrate 0.25% group, improvement was most marked among those with moderate or severe diaper dermatitis at baseline and among patients whose baseline rashes were positive for C. albicans. Treatment with miconazole nitrate 0.25% was as safe as with ointment base alone. Miconazole nitrate 0.25% ointment is a safe and effective treatment for diaper dermatitis in infants. |
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Authors:
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P Concannon; E Gisoldi; S Phillips; R Grossman |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Pediatric dermatology Volume: 18 ISSN: 0736-8046 ISO Abbreviation: Pediatr Dermatol Publication Date: 2001 Mar-Apr |
Date Detail:
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Created Date: 2001-05-18 Completed Date: 2001-07-26 Revised Date: 2009-03-03 |
Medline Journal Info:
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Nlm Unique ID: 8406799 Medline TA: Pediatr Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 149-55 Citation Subset: IM |
Affiliation:
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Royal North Shore Hospital, St. Leonards, New South Wales, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antifungal Agents
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adverse effects,
therapeutic use* Candida albicans / drug effects Candidiasis / complications, drug therapy Conjunctivitis / chemically induced Diaper Rash / complications, drug therapy*, pathology Double-Blind Method Female Fever / chemically induced Humans Infant Male Miconazole / adverse effects, therapeutic use* Patient Dropouts Severity of Illness Index Skin / drug effects, pathology Time Factors Treatment Outcome Vomiting / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 22916-47-8/Miconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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