| Diamino acid derivatives of porphyrins penetrate into yeast cells, induce photodamage, but have no mutagenic effect. | |
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MedLine Citation:
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PMID: 9277145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The yeast Saccharomyces cerevisiae was used as a model eukaryotic organism to study the uptake of diamino acid derivatives of porphyrins and their phototoxicity with particular emphasis on possible mutagenic effects. The water-soluble hematoporphyrin derivatives diarginate (HpD[Arg]2) and 1-arginin di(N-amino acid)-protoporphyrinate used in this study are effective photosensitizers in tumor photodynamic therapy. Depending on the amino acid substituent, the porphyrin derivatives differ in their affinity for yeast cells. It is shown that HpD(Arg)2 and PP(Met)2 (Arg)2 penetrate into the yeast cell and are metabolized. Both compounds sensitize yeast cells to photodamage but have no mutagenic effect on nuclear or mitochondrial genomes. |
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Authors:
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T Zoładek; B N Nguyen; I Jagiełło; A Graczyk; J Rytka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Photochemistry and photobiology Volume: 66 ISSN: 0031-8655 ISO Abbreviation: Photochem. Photobiol. Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1998-01-08 Completed Date: 1998-01-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376425 Medline TA: Photochem Photobiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 253-9 Citation Subset: IM |
Affiliation:
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Department of Genetics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland. teresa@ibbrain.ibb.waw.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids, Diamino
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metabolism*,
pharmacology Hematoporphyrins / chemistry, metabolism*, pharmacology Mutagenesis Photochemistry Photosensitizing Agents / chemistry, metabolism*, pharmacology Protoporphyrins / chemistry, metabolism*, pharmacology Saccharomyces cerevisiae / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Diamino; 0/Hematoporphyrins; 0/Photosensitizing Agents; 0/Protoporphyrins; 553-12-8/protoporphyrin IX |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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