Document Detail


Diamino acid derivatives of porphyrins penetrate into yeast cells, induce photodamage, but have no mutagenic effect.
MedLine Citation:
PMID:  9277145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The yeast Saccharomyces cerevisiae was used as a model eukaryotic organism to study the uptake of diamino acid derivatives of porphyrins and their phototoxicity with particular emphasis on possible mutagenic effects. The water-soluble hematoporphyrin derivatives diarginate (HpD[Arg]2) and 1-arginin di(N-amino acid)-protoporphyrinate used in this study are effective photosensitizers in tumor photodynamic therapy. Depending on the amino acid substituent, the porphyrin derivatives differ in their affinity for yeast cells. It is shown that HpD(Arg)2 and PP(Met)2 (Arg)2 penetrate into the yeast cell and are metabolized. Both compounds sensitize yeast cells to photodamage but have no mutagenic effect on nuclear or mitochondrial genomes.
Authors:
T Zoładek; B N Nguyen; I Jagiełło; A Graczyk; J Rytka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Photochemistry and photobiology     Volume:  66     ISSN:  0031-8655     ISO Abbreviation:  Photochem. Photobiol.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1998-01-08     Completed Date:  1998-01-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376425     Medline TA:  Photochem Photobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  253-9     Citation Subset:  IM    
Affiliation:
Department of Genetics, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland. teresa@ibbrain.ibb.waw.pl
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MeSH Terms
Descriptor/Qualifier:
Amino Acids, Diamino / metabolism*,  pharmacology
Hematoporphyrins / chemistry,  metabolism*,  pharmacology
Mutagenesis
Photochemistry
Photosensitizing Agents / chemistry,  metabolism*,  pharmacology
Protoporphyrins / chemistry,  metabolism*,  pharmacology
Saccharomyces cerevisiae / genetics,  metabolism*
Chemical
Reg. No./Substance:
0/Amino Acids, Diamino; 0/Hematoporphyrins; 0/Photosensitizing Agents; 0/Protoporphyrins; 553-12-8/protoporphyrin IX

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