Document Detail

Dialyzer hypersensitivity syndrome: possible role of allergy to ethylene oxide. Report of 4 cases and review of the literature.
MedLine Citation:
PMID:  3901757     Owner:  NLM     Status:  MEDLINE    
The occurrence of hypersensitivity reactions in patients dialyzed on artificial kidneys is well recognized in the dialysis community, but has received little attention in the medical literature. We report 4 cases of dialyzer hypersensitivity reactions and review the previously reported cases. Dialyzer hypersensitivity syndrome presents as an acute anaphylactoid reaction, the symptoms of which may range from mild to life threatening in severity. The cause of this syndrome is unknown, but affected patients appear to have a high incidence of positive radioallergosorbent tests to a conjugate of human serum albumin and ethylene oxide, suggesting that ethylene oxide, a substance used to dry sterilize artificial kidneys, may be an offending allergen.
R J Caruana; R W Hamilton; F C Pearson
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  American journal of nephrology     Volume:  5     ISSN:  0250-8095     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  1985  
Date Detail:
Created Date:  1985-11-21     Completed Date:  1985-11-21     Revised Date:  2007-02-14    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  271-4     Citation Subset:  IM    
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MeSH Terms
Anaphylaxis / etiology
Ethylene Oxide / adverse effects*
Hypersensitivity / etiology*
Kidney, Artificial / adverse effects
Middle Aged
Renal Dialysis / adverse effects*
Reg. No./Substance:
75-21-8/Ethylene Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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