Document Detail

Dialysis fluid temperature and vasoactive substances during routine hemodialysis.
MedLine Citation:
PMID:  8555600     Owner:  NLM     Status:  MEDLINE    
Blood pressure stability is better during cold hemodialysis (HD). This has mainly been attributed to a more pronounced sympathetic activation during cold than during warm HD. The authors studied the effect of dialysate temperature on vasoactive peptides, noradrenaline (NA), and renin (PRA). Ten hemodynamically stable patients were dialyzed for 240 min with each of two dialysate temperatures: 38.5 degrees C (warm HD = WHD) and 34.5 degrees C (cold HD = CHD). A decrease (P < 0.05) in blood pressure occurred during WHD; however, during CHD, blood pressure was stable. There were no differences in vasoconstrictors between the two regimens. There was a decrease in NA (P < 0.05), a tendency of PRA to increase (NS owing to a large statistical spread), while arginine vasopressin was unchanged. During CHD, there was a small increase in neuropeptide Y (NPY); however, during WHD, NPY only tended to increase. However, the relative NPY levels (percent of baseline levels) after WHD and CHD did not differ. The vasodilator response was similar during both treatments. Calcitonin gene related peptide was unaltered. Motilin tended to decrease initially, but then increased (P < 0.05) to baseline levels. An increase occurred in beta-endorphin (P < 0.05) and substance P(P < 0.01). There was an initial rise (P < 0.05) in vasoactive intestinal peptide (VIP), followed by a tendency to decrease during the remainder of treatment. The authors concluded that blood pressure stability was better during CHD. However, this was not reflected by differences in plasma levels of the vasoactive peptides, nor did they find any difference in the sympathetic drive between the two regimens.
J Hegbrant; L Mãrtensson; R Ekman; A L Nielsen; H Thysell
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  40     ISSN:  1058-2916     ISO Abbreviation:  ASAIO J.     Publication Date:    1994 Jul-Sep
Date Detail:
Created Date:  1996-02-26     Completed Date:  1996-02-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  M678-82     Citation Subset:  IM    
Department of Nephrology, University Hospital Lund, Sweden.
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MeSH Terms
Arginine Vasopressin / blood
Body Temperature
Calcitonin Gene-Related Peptide / blood
Hemodialysis Solutions*
Middle Aged
Motilin / blood
Neuropeptide Y / blood
Norepinephrine / blood*
Renal Dialysis / adverse effects*,  methods*
Renin / blood*
Substance P / blood
Vasoconstrictor Agents / blood
Vasodilator Agents / blood
beta-Endorphin / blood
Reg. No./Substance:
0/Hemodialysis Solutions; 0/Neuropeptide Y; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 113-79-1/Arginine Vasopressin; 33507-63-0/Substance P; 51-41-2/Norepinephrine; 52906-92-0/Motilin; 60617-12-1/beta-Endorphin; 83652-28-2/Calcitonin Gene-Related Peptide; EC

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