Document Detail

Diagonal ear-lobe crease is correlated with atherosclerotic changes in carotid arteries.
MedLine Citation:
PMID:  19644217     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The diagonal ear-lobe crease (ELC) is reported to be a marker of cardiovascular disease. Very few reports have assessed the relationship of ELC with atherosclerosis. This relationship is investigated here using a Japanese population. METHODS AND RESULTS: A prospective cross-sectional study included 212 consecutive patients. Bilateral ear lobes were checked for the ELC and this was followed by carotid ultrasonography to measure the far wall common carotid artery intima-media thickness (CCA-IMT), plaque score (PS) and plaque number (PN). Patients with ELC had significantly higher carotid IMT than controls (0.90 +/-0.24 vs 0.77 +/-0.15, respectively, P<0.001). ELC presence correlated significantly with carotid IMT, PS, and PN (r=0.306, P<0.0001; r=0.198, P<0.008 and r=0.221, P<0.0001, respectively), and also with age, male sex and hypertension. ELC presence and absence in mild or no PS and moderate or severe PS subgroups was significant, with a chi-squared value of 7.59 (P<0.006). In multivariate regression analysis, ELC presence correlated with CCA-IMT independently. The odds ratio for the presence of ELC in patients with CCA-IMT of <0.8 mm vs patients with CCA-IMT of >or=0.8 mm (the median value) was 0.41 (95% confidence interval, 0.22-0.76). CONCLUSIONS: The present study showed an association between ELC and increased CCA-IMT, PS, and PN.
Isha Shrestha; Toshiho Ohtsuki; Tetsuya Takahashi; Eiichi Nomura; Tatsuo Kohriyama; Masayasu Matsumoto
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Publication Detail:
Type:  Journal Article     Date:  2009-07-31
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  73     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-25     Completed Date:  2009-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1945-9     Citation Subset:  IM    
Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences, Japan.
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MeSH Terms
Aged, 80 and over
Asian Continental Ancestry Group
Carotid Artery Diseases / ethnology,  ultrasonography*
Carotid Artery, Common / ultrasonography*
Case-Control Studies
Cross-Sectional Studies
Ear, External / anatomy & histology*
Middle Aged
Odds Ratio
Predictive Value of Tests
Prospective Studies
Risk Assessment
Risk Factors
Severity of Illness Index
Tunica Intima / ultrasonography
Tunica Media / ultrasonography
Ultrasonography, Doppler, Duplex*
Comment In:
Circ J. 2009 Oct;73(10):1801-2   [PMID:  19779275 ]

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