Document Detail

Diagnostic yield and safety of ultrasound-assisted biopsies in superior vena cava syndrome.
MedLine Citation:
PMID:  19213788     Owner:  NLM     Status:  MEDLINE    
The yield and safety of ultrasound (US)-assisted transthoracic fine needle aspirations (TTFNA) and cutting needle biopsies (CNB) in the setting of superior vena cava (SVC) syndrome are unknown. The aims of the present prospective study were to asses the diagnostic yield and safety of US-assisted TTFNA and CNB in SVC syndrome with an associated mass lesion abutting the chest wall. Over a 3-yr period, the present authors screened 59 patients with SVC syndrome, and enrolled 25 patients who had an associated mass lesion that extended to the chest wall. US-assisted TTFNA with rapid on-site evaluation (ROSE) was performed in all cases. CNBs were performed where a provisional diagnosis of bronchogenic carcinoma could not be established, and in 57.1% of patients with bronchogenic carcinoma (limited due to safety constraints). ROSE of US-assisted TTFNA confirmed diagnostically useful material in 24 patients, and cytological diagnoses were ultimately made in all of these cases (diagnostic yield 96%). US-assisted CNB had a diagnostic yield of 87.5%. Minor haemorrhage occurred in one out of 25 TTFNA and three out of 16 CNB. Neither procedure resulted in major haemorrhage nor pneumothoraces. US-assisted TTFNA and CNB have a high diagnostic yield and are safe in the setting of SVC syndrome with an associated mass lesion abutting the chest wall.
C F N Koegelenberg; C T Bolliger; D Plekker; C A Wright; K Brundyn; M Louw; P Schubert; M M van den Heuvel; A H Diacon
Publication Detail:
Type:  Journal Article     Date:  2009-02-12
Journal Detail:
Title:  The European respiratory journal     Volume:  33     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-01     Completed Date:  2009-09-17     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1389-95     Citation Subset:  IM    
Division of Pulmonology, Dept of Medicine, University of Stellenbosch, Tygerberg, Cape Town, South Africa.
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MeSH Terms
Biopsy, Fine-Needle / adverse effects,  methods*
Chi-Square Distribution
Diagnosis, Differential
Flow Cytometry
Prospective Studies
Sensitivity and Specificity
Superior Vena Cava Syndrome / diagnosis*,  pathology,  ultrasonography
Tomography, X-Ray Computed
Ultrasonography, Interventional*

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