| Diagnostic yield of the lactate stress test in respiratory chain disorders under absolute and relative workload. | |
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MedLine Citation:
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PMID: 11459619 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Usually, the lactate stress test is carried under a constant, low workload maintained for 15 min, although there are indications that the lactate response to exercise is a function of the relative workload, and that a workload for only 5 min does not decrease its sensitivity. Thus, this study compared the diagnostic yield of the lactate stress test when carried out under a constant workload of 30 W (LSTA) and under a workload of 30% of maximum (LSTR), and when the workload was maintained for 5 and 15 min. In 16 patients with respiratory chain disorders, 12 women, four men, aged 27--88 years, the LSTA and LSTR were carried out on 2 different days, within 48 h. For both tests serum lactate was determined before, during and after a 15-min workload on a bicycle. Upper reference limits at rest, 5, 10, 15 min after starting, and 15 min after finishing the exercise were 1.9, 2.0, 2.0, 2.0, and 1.6 mmol/l for the LSTA, and 2.3, 3.0, 3.2, 3.4 and 2.7 mmol/l for the LSTR. The sensitivity was 88% for the LSTA and 63% for the LSTR. The specificity of the LSTA was 94%. The diagnostic yield of both tests was similar when the workload was maintained for 5 or 15 min. In conclusion, the LSTA should be preferred to the LSTR. Three lactate determinations during 15 min have no advantage over a single lactate determination after a 5 min workload of 30 W. |
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Authors:
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J Finsterer; E Milvay |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neuroscience methods Volume: 108 ISSN: 0165-0270 ISO Abbreviation: J. Neurosci. Methods Publication Date: 2001 Jul |
Date Detail:
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Created Date: 2001-07-18 Completed Date: 2001-09-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7905558 Medline TA: J Neurosci Methods Country: Netherlands |
Other Details:
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Languages: eng Pagination: 65-70 Citation Subset: IM |
Affiliation:
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Ludwig Boltzmann Institute for Research in Neuromuscular Disorders, Postfach 348, 1180 Vienna, Austria. fij@2nr.nkr.magiwien.gv.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Electron Transport / physiology* Exercise Test / methods* Exercise Tolerance / physiology* Female Humans Lactic Acid / analysis*, blood* Male Middle Aged Mitochondrial Myopathies / blood*, diagnosis*, physiopathology Muscle, Skeletal / metabolism, physiopathology Workload* |
| Chemical | |
Reg. No./Substance:
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50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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