Document Detail

Diagnostic yield of the lactate stress test in respiratory chain disorders under absolute and relative workload.
MedLine Citation:
PMID:  11459619     Owner:  NLM     Status:  MEDLINE    
Usually, the lactate stress test is carried under a constant, low workload maintained for 15 min, although there are indications that the lactate response to exercise is a function of the relative workload, and that a workload for only 5 min does not decrease its sensitivity. Thus, this study compared the diagnostic yield of the lactate stress test when carried out under a constant workload of 30 W (LSTA) and under a workload of 30% of maximum (LSTR), and when the workload was maintained for 5 and 15 min. In 16 patients with respiratory chain disorders, 12 women, four men, aged 27--88 years, the LSTA and LSTR were carried out on 2 different days, within 48 h. For both tests serum lactate was determined before, during and after a 15-min workload on a bicycle. Upper reference limits at rest, 5, 10, 15 min after starting, and 15 min after finishing the exercise were 1.9, 2.0, 2.0, 2.0, and 1.6 mmol/l for the LSTA, and 2.3, 3.0, 3.2, 3.4 and 2.7 mmol/l for the LSTR. The sensitivity was 88% for the LSTA and 63% for the LSTR. The specificity of the LSTA was 94%. The diagnostic yield of both tests was similar when the workload was maintained for 5 or 15 min. In conclusion, the LSTA should be preferred to the LSTR. Three lactate determinations during 15 min have no advantage over a single lactate determination after a 5 min workload of 30 W.
J Finsterer; E Milvay
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neuroscience methods     Volume:  108     ISSN:  0165-0270     ISO Abbreviation:  J. Neurosci. Methods     Publication Date:  2001 Jul 
Date Detail:
Created Date:  2001-07-18     Completed Date:  2001-09-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905558     Medline TA:  J Neurosci Methods     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  65-70     Citation Subset:  IM    
Ludwig Boltzmann Institute for Research in Neuromuscular Disorders, Postfach 348, 1180 Vienna, Austria.
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MeSH Terms
Aged, 80 and over
Electron Transport / physiology*
Exercise Test / methods*
Exercise Tolerance / physiology*
Lactic Acid / analysis*,  blood*
Middle Aged
Mitochondrial Myopathies / blood*,  diagnosis*,  physiopathology
Muscle, Skeletal / metabolism,  physiopathology
Reg. No./Substance:
50-21-5/Lactic Acid

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