| Diagnostic workup for mixed connective tissue disease in childhood. | |
| | |
MedLine Citation:
|
PMID: 18847172 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Raynaud's phenomenon, fatigue and pain (myalgia and arthralgia) are important presenting symptoms of pediatric-onset mixed connective tissue disease. The difficulty is that many adolescent girls complain of pain along with fatigue without evidence for serious disease. However, in patients with Raynaud's phenomenon one should search for evidence of connective tissue diseases. Capillaroscopy could be helpful since capillary changes of the SD-type significantly correlate with future development of scleroderma spectrum disorders. Symptoms of MCTD change in most patients during the disease course: in general the inflammatory features that are also seen in systemic lupus erythematosus and juvenile dermatomyositis have the tendency to disappear over years, but Raynaud's phenomenon is persistent and scleroderma symptoms become progressively prominent. Long-lasting remission occurs only in a minority of patients, while the majority has mild disease activity. Mortality in children with MCTD is lower than in adults. Since a change of symptoms is in the nature of the disease, a thorough and frequent evaluation of children with (probable) MCTD is important to detect organ involvement, which should be treated at an early (pre-symptomatic) stage. We present a diagnostic workup scheme for children and adolescents with propable MCTD. |
| | |
Authors:
|
Joost F Swart; Nico M Wulffraat |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: The Israel Medical Association journal : IMAJ Volume: 10 ISSN: 1565-1088 ISO Abbreviation: Isr. Med. Assoc. J. Publication Date: 2008 Aug-Sep |
Date Detail:
|
Created Date: 2008-10-13 Completed Date: 2008-11-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100930740 Medline TA: Isr Med Assoc J Country: Israel |
Other Details:
|
Languages: eng Pagination: 650-2 Citation Subset: IM |
Affiliation:
|
VU University Medical Center, Amsterdam, The Netherlands. swart@vumc.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Child Fatigue / complications Humans Mixed Connective Tissue Disease / complications, diagnosis* Pain / complications Raynaud Disease / complications |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Two-dose measles immunization as a strategy to eliminate measles in the Middle East and Israel.
Next Document: Surveillance of nosocomial infections: a preliminary study on yeast carriage on hands of healthcare ...