Document Detail

Diagnostic value of routine clinical parameters in acute myocardial infarction: a comparison to delayed contrast enhanced magnetic resonance imaging. Delayed enhancement and routine clinical parameters after myocardial infarction.
MedLine Citation:
PMID:  14609190     Owner:  NLM     Status:  MEDLINE    
AIMS: Contrast enhanced magnetic resonance imaging (ceMRI) has been shown to reliably identify irreversible myocardial injury. The aim of this study was to compare the findings on ceMRI with routine clinical markers of myocardial injury in patients with acute myocardial infarction (MI). METHODS AND RESULTS: Twenty-four patients with acute MI were investigated at 1.5 T. The global myocardial function was analysed with a standard cine MR protocol and a stack of short axis slices encompassing the entire left ventricle. Corresponding short axis slices were acquired for delayed ceMRI 15-20 min after the administration of 0.2 mmol gadolinium-DTPA/kg body weight. Mass of hyperenhancement and peak creatine kinase release (peak CK) was determined for each patient. The presenting 12-lead ECG was analysed for ST-elevation on admission and later development of Q-waves. Mass of hyperenhancement correlated moderately well to peak CK (r = 0.65, p < 0.01) and endsystolic volume index (r = 0.55, p < 0.01). Mass of hyperenhancement was inversely correlated to ejection fraction (r = -0.50, p = 0.02). Neither the presence of ST elevation on the admission ECG nor the later development of Q-waves did relate to the transmural extent of hyperenhancement and to the mass of hyperenhancement. CONCLUSION: Mass of hyperenhancement significantly correlates to global myocardial function and to peak CK. However, there is no relationship between the findings in ceMRI and 12-lead ECG abnormalities on admission suggesting an advantage of ceMRI in defining transmural extent and depicting small areas of necrosis.
Steffen E Petersen; Georg Horstick; Thomas Voigtländer; Karl-Friedrich Kreitner; Thomas Wittlinger; Steffen Ziegler; Nico Abegunewardene; Melanie Schmitt; Wolfgang G Schreiber; Peter Kalden; Oliver K Mohrs; Manfred Thelen; Juergen Meyer
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  The international journal of cardiovascular imaging     Volume:  19     ISSN:  1569-5794     ISO Abbreviation:  Int J Cardiovasc Imaging     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-11-11     Completed Date:  2004-04-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100969716     Medline TA:  Int J Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  409-16     Citation Subset:  IM    
2nd Medical Clinic, University Hospital Mainz, Germany.
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MeSH Terms
Biological Markers / blood
Contrast Media
Coronary Angiography
Creatine Kinase / blood
Diagnostic Tests, Routine*
Heart Ventricles / physiopathology,  radiography
Magnetic Resonance Imaging
Middle Aged
Myocardial Infarction / blood,  diagnosis*,  physiopathology
Radiographic Image Enhancement
Statistics as Topic
Stroke Volume / physiology
Time Factors
Reg. No./Substance:
0/Biological Markers; 0/Contrast Media; EC Kinase
Comment In:
Int J Cardiovasc Imaging. 2003 Oct;19(5):417-8   [PMID:  14609191 ]

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