| Diagnostic value of proinflammatory interleukins in parapneumonic effusions. | |
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MedLine Citation:
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PMID: 20472846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pleural effusion appears in approximately 40% of patients with pneumonia. Given that microbiology results are often negative, its diagnosis is frequently based on clinical criteria. Our study consisted of 266 patients, divided into infectious (n = 34), tuberculous (n = 54), paraneoplastic (n = 63), miscellaneous exudates (n = 53), and transudates (n = 62). Interleukin (IL)-6, IL-8, and IL-1beta were measured in the pleural fluid and serum of all patients, as well as the different cell populations in the pleural fluid. Analysis of the receiver operating characteristic curves of the different ILs in pleural fluid for the diagnosis of parapneumonic/empyematous effusion showed IL-6 with a sensitivity of 38.2% and specificity of 97.4%, IL-8 with a sensitivity of 73.5% and specificity of 65.1%, IL-1beta with a sensitivity of 55.6% and specificity of 91.3%, and total neutrophil count in pleural fluid (PNEU) with a sensitivity of 62.9% and specificity of 91.1%. The combination of IL-1beta and PNEU improved the yield, with a sensitivity of 75.7% and a specificity of 83.1%. |
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Authors:
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M Esther San Jos?; Luis Valdes; F Javier Gonzalez-Barcala; Luis Vizcaino; Manuel Garrido; Angeles Sanmartin; Sara Mougan; Antonio Pose; Angel Segade |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of clinical pathology Volume: 133 ISSN: 1943-7722 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-17 Completed Date: 2010-06-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 884-91 Citation Subset: AIM; IM |
Affiliation:
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Bioqu?mica Especial, Central Laboratory and Department of Pneumology, Complejo Hospitalario Universitario de Santiago de Compostela, La Coru?a, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Humans Interleukin-1beta / blood Interleukin-6 / blood Interleukin-8 / blood Interleukins / analysis* Leukocyte Count Male Middle Aged Neutrophils / cytology Pleural Effusion / blood*, diagnosis Retrospective Studies Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1beta; 0/Interleukin-6; 0/Interleukin-8; 0/Interleukins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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