Document Detail

Diagnostic value of optical coherence tomography for intracranial pressure in idiopathic intracranial hypertension.
MedLine Citation:
PMID:  22592348     Owner:  NLM     Status:  Publisher    
BACKGROUND: Idiopathic intracranial hypertension (IIH) is a condition of raised intracranial pressure (ICP) in the absence of space-occupying lesions or other known etiology. It primarily affects young obese females, and potentially causes permanent visual loss due to papilledema and secondary optic atrophy. The aim of this study was to evaluate the diagnostic value of optical coherence tomography (OCT) as a marker for CSF opening pressure in patients with idiopathic intracranial hypertension (IIH). METHODS: We conducted a case-control study of 20 newly diagnosed, 21 long-term IIH patients, and 20 healthy controls. Investigations included measurement of peripapillary retinal nerve fiber layer thickness (RNFLT) and total retinal thickness (RT), automated visual field testing, and measurement of CSF opening pressure. An OCT elevation diagram was developed as a new diagnostic tool. The diagnostic ability of OCT as a marker of increased ICP (> 25 cmH(2)O) was investigated using multiple regression and receiver operating characteristic (ROC) curves. RESULTS: OCT elevation diagrams showed that in 60 % of patients newly diagnosed with IIH and in 10 % of patients with long-term IIH, 50 % or more of the OCT scans (RT and RNFLT) were above normal. The percentage of abnormal OCT scans was significantly associated with increased ICP (p < 0.0001). Estimated areas under the ROC curves increased from 77.1 to 86.9 by including OCT in multiple regressions. Autoperimetry pattern standard deviation was significantly increased (p = 0.0005) and mean deviation was significantly decreased (p = 0.0005) in IIH patients as compared to healthy controls. CONCLUSIONS: Increased peripapillary retinal thickness measured by OCT is associated with increased ICP in newly diagnosed IIH patients. OCT may thus serve as a valuable supplement to subjective assessment of papilledema in patients suspected of having IIH. In long-term IIH patients who have previously been treated, OCT appears to be of limited value in predicting ICP.
Maren Skau; Hanne Yri; Birgit Sander; Thomas A Gerds; Dan Milea; Rigmor Jensen
Related Documents :
22495458 - Venous hypertension as the cause of intracranial hypertension in patients with transver...
8489558 - Cardiotonic activity of the water soluble forskolin derivative 8,13-epoxy-6 beta-(piper...
7499398 - Pressure-induced dissociation and denaturation of allophycocyanin at subzero temperatures.
2552728 - Impaired acth and beta-endorphin response to sauna-induced hyperthermia in heroin addicts.
1999358 - Preservation of renal function by angiotensin during chronic adrenergic stimulation.
15702628 - Current status of hypertension control around the world.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-18
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie     Volume:  -     ISSN:  1435-702X     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Danish Headache Center, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 69, 2600, Glostrup, Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  [Ocular involvement in stevens-johnson syndrome and toxic epidermal necrolysis].
Next Document:  Self-assembly driven by an aromatic primary amide motif.