| Diagnostic value of nasal provocation testing and rhinomanometry in allergic rhinitis. | |
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MedLine Citation:
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PMID: 8807509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied 32 patients, aged 7 to 17 years, with clinical symptoms of perennial allergic rhinitis, isolated (n = 21) or associated with asthma (n = 11), all of them with positive skin test and specific serum IgE for Dermatophagoides pteronyssinus (Dpt). The control group consisted of 10 children aged 7 to 16 years, with no personal or family history of allergy and with negative skin tests and negative specific serum IgE for mites. Total and specific IgE measurements in nasal secretion and nasal provocation testing (NPT) were also performed with increasing concentrations of Dermatophagoides pteronyssinus (Dpt) extracts. The nasal response was evaluated using a clinical score and active anterior rhinomanometry. The levels of total and specific IgE in nasal secretion were higher in patients with allergic rhinitis than in individuals from the control group. The NPT presented a significant correlation with clinical symptoms, skin tests and specific serum IgE. None of the individuals from the control group presented a positive NPT. No generalized reactions or bronchial response at the immediate phase of NPT were observed. The NPT constitutes a safe, dependable investigative procedure of nasal reactivity to a specific allergen, presenting a good sensitivity and specificity when compared to the other methods classically used in allergy studies. |
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Authors:
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F R Fernandes; D Solé; C Naspitz; F Muñoz-López |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunología Volume: 6 ISSN: 1018-9068 ISO Abbreviation: J Investig Allergol Clin Immunol Publication Date: 1996 May-Jun |
Date Detail:
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Created Date: 1997-01-21 Completed Date: 1997-01-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107858 Medline TA: J Investig Allergol Clin Immunol Country: SPAIN |
Other Details:
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Languages: eng Pagination: 184-8 Citation Subset: IM |
Affiliation:
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Universidade Federal de São Pãulo, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Allergens / immunology Antigens, Dermatophagoides Child Glycoproteins / immunology Humans Immunoglobulin E / analysis Manometry Nasal Mucosa / immunology, secretion Nasal Provocation Tests* / statistics & numerical data Predictive Value of Tests Rhinitis, Allergic, Perennial / diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Antigens, Dermatophagoides; 0/Glycoproteins; 37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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