Document Detail

Diagnostic value of lung clearance of 99mTc DTPA compared with other non-invasive investigations in Pneumocystis carinii pneumonia in AIDS.
MedLine Citation:
PMID:  1750019     Owner:  NLM     Status:  MEDLINE    
Various non-invasive investigations were carried out in patients infected with HIV who had respiratory symptoms with and without pneumocystis pneumonia (with pneumonia, n = 13 (five smokers); without pneumonia, n = 22 (13 smokers]. These included chest radiography; lung function tests (forced expiratory volume in one second, forced vital capacity; transfer factor and coefficient for carbon monoxide); arterial blood gas tensions; arterial oxygen saturation at rest and on exercise; and lung clearance of diethylenetriaminepenta-acetic acid labelled with technetium-99m (99mTc DTPA). The effect of scan time (seven v 45 minutes from peak counts) and subtraction of background counts were examined. There were no significant differences between the two groups in lung function tests or arterial blood gas tensions at rest. The median clearance half time of inhaled 99mTc DTPA for the first seven minutes from peak counts was 7.2 minutes for patients with pneumocystis pneumonia and 22 minutes for those without. The median arterial oxygen desaturation on exercise was 5% in patients with pneumocystis pneumonia and 2% in those without. 99mTc DTPA lung clearance was better than the other non-invasive tests in discriminating pneumocystis pneumonia from other pulmonary disorders in patients positive for HIV. A short scan time of seven minutes was as sensitive and specific as the longer scan time of 45 minutes, and this allows the clearance of 99mTc DTPA to become a rapid screening test.
D S Robinson; D A Cunningham; S Dave; J Fleming; D M Mitchell
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Thorax     Volume:  46     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1992-01-22     Completed Date:  1992-01-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  722-6     Citation Subset:  IM; X    
Department of Respiratory Medicine, St Mary's Hospital, London.
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MeSH Terms
HIV Seropositivity / complications*
Lung / radionuclide imaging*
Middle Aged
Opportunistic Infections / blood,  complications,  diagnosis,  radionuclide imaging*
Oxygen / blood
Pneumonia, Pneumocystis / blood,  complications,  diagnosis,  radionuclide imaging*
Technetium Tc 99m Pentetate / diagnostic use*
Reg. No./Substance:
65454-61-7/Technetium Tc 99m Pentetate; 7782-44-7/Oxygen
Comment In:
Thorax. 1992 Feb;47(2):138   [PMID:  1549824 ]
Thorax. 1992 Jul;47(7):575-6   [PMID:  1412109 ]

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