Document Detail

Diagnostic value of ischaemia-modified albumin for predicting myocardial ischaemia during myocardial perfusion scintigraphy.
MedLine Citation:
PMID:  18304413     Owner:  NLM     Status:  MEDLINE    
During acute ischaemia the N-terminal site of albumin is altered, reducing its binding capacity; the modified protein is termed ischaemia-modified albumin (IMA). IMA is a sensitive marker of acute myocardial ischaemia but its diagnostic value in chronic angina pectoris patients is unclear. We investigated changes in blood levels of IMA during myocardial perfusion scintigraphy in patients with chronic angina pectoris in a study including 26 male and 20 female patients, with mean age 60 years. Technetium 99m perfusion imaging detected myocardial ischaemia in 26 patients. Coronary angiography was carried out in these 26 ischaemic patients. Mean IMA values at rest and peak exercise were significantly higher in the ischaemic than the nonischaemic group. All IMA values were considered negative for cardiac ischaemia. Peak exercise IMA was significantly lower than the pre-exercise level only in the non-ischaemic group. IMA measurements during myocardial perfusion scintigraphy are not helpful in the diagnosis of myocardial ischaemia in patients with stable angina pectoris.
B Y Cingozbay; N Ozmen; N Canbolat; M Aparci; E Kardeşoğlu; Y Narin; M Gultepe; B S Cebeci; M Dincturk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of international medical research     Volume:  36     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2008 Jan-Feb
Date Detail:
Created Date:  2008-02-28     Completed Date:  2008-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  147-51     Citation Subset:  IM    
Department of Cardiology, Gulhane Military Medical Academy Haydarpasa Teaching Hospital, Istanbul, Turkey.
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MeSH Terms
Angina Pectoris / blood,  diagnosis*
Biological Markers / analysis*
Chronic Disease
Coronary Angiography
Coronary Artery Disease / blood,  diagnosis
Exercise Test
Middle Aged
Myocardial Ischemia / blood,  diagnosis*
Myocardial Reperfusion*
Predictive Value of Tests
Radionuclide Imaging / methods*
Serum Albumin / analysis*
Technetium / diagnostic use
Reg. No./Substance:
0/Biological Markers; 0/Serum Albumin; 7440-26-8/Technetium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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