Document Detail

Diagnostic value of homocysteine, C-reactive protein and bilirubin for coronary artery disease.
MedLine Citation:
PMID:  17687824     Owner:  NLM     Status:  MEDLINE    
We evaluated 3 new markers for coronary artery disease (CAD) [bilirubin, total homocysteine (t-Hcy) and high-sensitivity C-reactive protein (hs-CRP)] in 319 patients with chest pains divided into 2 groups based on coronary angiography: CAD group (n = 262) and non-CAD group (n = 57). A control group consisted of 50 healthy subjects. t-Hcy had the highest diagnostic value for diagnosis of angiographically documented patients; bilirubin had the lowest. The sensitivities and specificities (based on ROC curves) of bilirubin, hs-CRP and t-Hcy were 70.9%, 50% and 76.8% respectively, and 40.4%, 80.7% and 70.2% respectively. We conclude that serum bilirubin levels cannot identify people at risk of CAD and t-Hcy and hs-CRP may be stronger markers.
N Yilmaz; H K Ciçek; A Celik; I Meram; R Kocabas; V Davutoglu
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Publication Detail:
Type:  Journal Article; Validation Studies    
Journal Detail:
Title:  Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ     Volume:  13     ISSN:  1020-3397     ISO Abbreviation:  East. Mediterr. Health J.     Publication Date:    2007 May-Jun
Date Detail:
Created Date:  2007-08-10     Completed Date:  2007-09-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9608387     Medline TA:  East Mediterr Health J     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  522-35     Citation Subset:  IM    
Department of Biochemistry, Gaziantep University Medical School, Gaziantep, Turkey.
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MeSH Terms
Analysis of Variance
Area Under Curve
Bilirubin / blood*
Biological Markers / blood
C-Reactive Protein / metabolism*
Case-Control Studies
Chest Pain / etiology
Chi-Square Distribution
Coronary Angiography
Coronary Artery Disease / blood*,  complications,  diagnosis*
Homocysteine / blood*
Logistic Models
Middle Aged
ROC Curve
Risk Factors
Sensitivity and Specificity
Statistics, Nonparametric
Reg. No./Substance:
0/Biological Markers; 454-28-4/Homocysteine; 635-65-4/Bilirubin; 9007-41-4/C-Reactive Protein

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