Document Detail

Diagnostic value of ferritin in malignant pleural and peritoneal effusions.
MedLine Citation:
PMID:  3191455     Owner:  NLM     Status:  MEDLINE    
The diagnostic usefulness of ferritin measurements in pleural and peritoneal effusions has been evaluated in 57 patients. Mean (+/- standard error [SE]) ferritin levels were 291 +/- 50 ng/ml in 24 patients with noninflammatory transudates (Group I), 942 +/- 253 in 15 patients with nonmalignant exudates (Group II), and 1805 +/- 257 in 18 patients with malignant exudates (Group III). The mean (+/- SE) ratio of effusion/serum ferritin in Groups I, II, and III was 0.7 +/- 0.1, 2.7 +/- 0.7, and 5.7 +/- 1.2, respectively. The specificity and predictive value of a ferritin ratio in excess of 1.5 in distinguishing transudates from all exudates and in distinguishing transudates from malignant exudates were both very high (94%) to 96%). In the lower range of values considerable overlap existed between ferritin ratios obtained in patients with benign versus malignant inflammatory exudates. However, very high ferritin levels (greater than 3000 ng/ml) and ferritin ratios (greater than 20:1) were only encountered in malignant exudates. These results indicate that the measurement of ferritin levels and ferritin ratios may be a useful aid in the diagnosis of malignant pleural and peritoneal effusions.
A Yinnon; A M Konijn; G Link; J Moreb; C Hershko
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer     Volume:  62     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-06     Completed Date:  1989-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2564-8     Citation Subset:  AIM; IM    
Department of Medicine, Shaare Zedek Medical Center, Jerusalem, Israel.
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MeSH Terms
Aged, 80 and over
Ascitic Fluid / diagnosis*
Ferritins / analysis*
Middle Aged
Neoplasms / diagnosis*
Pleural Effusion / diagnosis*
Reg. No./Substance:

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