Document Detail


Diagnostic value of detecting fusion proteins derived from chromosome translocations in acute leukaemia.
MedLine Citation:
PMID:  14592649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clonal chromosomal abnormalities such as balanced translocations are characteristic features of several human leukaemias and have long been detected by conventional cytogenetics on banded metaphases. The advent of molecular biology techniques, advanced karyotyping and immunohistochemistry methods has not only allowed identification of gene involvement at altered chromosome sites and better knowledge of leukaemia pathogenesis, but also contributed important improvements in diagnosis of these heterogeneous diseases. Such novel diagnostic strategies are nowadays being increasingly used to improve leukaemia classification, and in several instances, they help to establish the most appropriate therapeutic strategy in individual patients. Moreover, at least two leukaemia-associated fusion proteins derived from chromosome translocation are specifically targeted by therapeutic approaches which result in significantly increased anti-leukaemia efficacy and reduced toxicity. In this chapter, we highlight the importance of identifying these genetic lesions at diagnosis in acute leukaemia. Further, we discuss briefly the clinical utility of detecting these alterations for prognostic assessment and evaluation of response to treatment.
Authors:
Francesco Lo-Coco; Massimo Breccia; Nélida Noguera; Wilson H Miller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Best practice & research. Clinical haematology     Volume:  16     ISSN:  1521-6926     ISO Abbreviation:  Best Pract Res Clin Haematol     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-10-31     Completed Date:  2004-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101120659     Medline TA:  Best Pract Res Clin Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  653-70     Citation Subset:  IM    
Affiliation:
Dipartimento di Biopatologia e Diagnostica per Immagini, University 'Tor Vergata', Via Montpellier 1, 00133, Rome, Italy. francesco.lo.cocco@uniroma2.it
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Humans
Leukemia / diagnosis*,  genetics
Oncogene Proteins, Fusion / analysis*,  genetics
Translocation, Genetic*
Chemical
Reg. No./Substance:
0/Oncogene Proteins, Fusion

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