Document Detail

Diagnostic value of detecting fusion proteins derived from chromosome translocations in acute leukaemia.
MedLine Citation:
PMID:  14592649     Owner:  NLM     Status:  MEDLINE    
Clonal chromosomal abnormalities such as balanced translocations are characteristic features of several human leukaemias and have long been detected by conventional cytogenetics on banded metaphases. The advent of molecular biology techniques, advanced karyotyping and immunohistochemistry methods has not only allowed identification of gene involvement at altered chromosome sites and better knowledge of leukaemia pathogenesis, but also contributed important improvements in diagnosis of these heterogeneous diseases. Such novel diagnostic strategies are nowadays being increasingly used to improve leukaemia classification, and in several instances, they help to establish the most appropriate therapeutic strategy in individual patients. Moreover, at least two leukaemia-associated fusion proteins derived from chromosome translocation are specifically targeted by therapeutic approaches which result in significantly increased anti-leukaemia efficacy and reduced toxicity. In this chapter, we highlight the importance of identifying these genetic lesions at diagnosis in acute leukaemia. Further, we discuss briefly the clinical utility of detecting these alterations for prognostic assessment and evaluation of response to treatment.
Francesco Lo-Coco; Massimo Breccia; Nélida Noguera; Wilson H Miller
Related Documents :
3282429 - Cutaneous and pericardial extramedullary hematopoiesis with cardiac tamponade in chroni...
19150599 - Awake fibreoptic intubation in neurosurgery.
16704059 - Anaerobic transformation of a technical brominated diphenyl ether mixture by super-redu...
22103519 - Chromobility: the rapid movement of chromosomes in interphase nuclei.
15672989 - Pneumomediastinum in student aviators: 10 cases with return to flying duty.
2747289 - Translocation (3;21) in philadelphia positive chronic myeloid leukemia: high resolution...
3937829 - The h-2 complex affects the frequency of urethan-induced chromosomal aberrations.
21961939 - Development of a set of compensating triticum aestivum - dasypyrum villosum robertsonia...
12930739 - Associations between inverted repeats and the structural evolution of bacterial genomes.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Best practice & research. Clinical haematology     Volume:  16     ISSN:  1521-6926     ISO Abbreviation:  Best Pract Res Clin Haematol     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-10-31     Completed Date:  2004-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101120659     Medline TA:  Best Pract Res Clin Haematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  653-70     Citation Subset:  IM    
Dipartimento di Biopatologia e Diagnostica per Immagini, University 'Tor Vergata', Via Montpellier 1, 00133, Rome, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Leukemia / diagnosis*,  genetics
Oncogene Proteins, Fusion / analysis*,  genetics
Translocation, Genetic*
Reg. No./Substance:
0/Oncogene Proteins, Fusion

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Gene expression profiling: will it complement or replace immunophenotyping?
Next Document:  How to optimize multiparameter flow cytometry for leukaemia/lymphoma diagnosis.