| Diagnostic value of SPECT, PET and PET/CT in the diagnosis of coronary artery disease: A systematic review. | |
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MedLine Citation:
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PMID: 22287989 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: The purpose of the study was to investigate the diagnostic value of SPECT, PET and PET/CT in the diagnosis of coronary artery disease, based on a systematic review. MATERIAL AND METHODS: A search of PubMed/Medline and Sciencedirect databases in the English-language literature published over the last 24 years was performed. Only studies with at least 10 patients comparing SPECT, PET or combined PET/CT with invasive coronary angiography in the diagnosis of coronary artery disease (50% stenosis) were included for analysis. Sensitivities and specificities estimates pooled across studies were analysed using a Chi-square test. RESULTS: Twenty-five studies met the selection criteria and were included for the analysis. Ten studies were performed with SPECT alone; while another six studies were performed with PET alone. Five studies were carried out with both PET and SPECT modalities, and the remaining four studies were investigated with integrated PET-CT. The mean value of sensitivity, specificity and accuracy of these imaging modalities for the diagnosis of coronary artery disease was 82% (95%CI: 76 to 88), 76% (95%CI: 70 to 82) and 83% (95%CI: 77 to 89) for SPECT; 91% (95%CI: 85 to 97), 89% (95%CI: 83 to 95) and 89% (95%CI: 83 to 95) for PET; and 85% (95%CI: 79 to 90), 83% (95%CI: 77 to 89) and 88% (95%CI: 82 to 94) for PET/CT, respectively. The diagnostic accuracy of these imaging modalities was dependent on the radiotracers used in these studies, with ammonia resulting in the highest diagnostic value. CONCLUSION: Our review shows that PET has high diagnostic value for diagnosing coronary artery disease, and this indicates that it is a valuable technique for both detection and prediction of coronary artery disease. |
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Authors:
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M Al Moudi; Z Sun; N Lenzo |
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Publication Detail:
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Type: Journal Article Date: 2011-04-01 |
Journal Detail:
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Title: Biomedical imaging and intervention journal Volume: 7 ISSN: 1823-5530 ISO Abbreviation: Biomed Imaging Interv J Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2012-01-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101258681 Medline TA: Biomed Imaging Interv J Country: Malaysia |
Other Details:
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Languages: eng Pagination: e9 Citation Subset: - |
Affiliation:
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Discipline of Medical Imaging, Curtin University of Technology, Perth, Western Australia, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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