Document Detail

Diagnostic value of MUC4 immunostaining in distinguishing epithelial mesothelioma and lung adenocarcinoma.
MedLine Citation:
PMID:  14657954     Owner:  NLM     Status:  MEDLINE    
The distinction between pleural malignant mesothelioma and pleural infiltration by adenocarcinomas has complex therapeutic and medicolegal implications. Although the panel of adenocarcinoma-associated antibodies and one or two mesothelioma markers is useful in this purpose, most of these antibodies are not totally specific. We determined the diagnostic value of MUC4 immunostaining in this issue. MUC4 gene expression was also studied by in situ hybridization and RT-PCR. MUC4 is a membrane-bound mucin that has been suggested to be implicated in malignant progression in humans and rats. The MUC4 gene is expressed in various normal epithelial tissues of endodermic origin and carcinomas. In the respiratory tract, MUC4 transcripts have been detected in normal respiratory epithelium and lung carcinomas. MUC4 protein was expressed in 32 of 35 (91.4%) lung adenocarcinomas on paraffin-embedded tissue. None of the 41 malignant mesotheliomas nor the 32 cases of benign mesothelial cells expressed MUC4 at the protein and mRNA levels. We conclude that MUC4 is a very specific (100%) and sensitive (91.4%) marker of lung adenocarcinomas on paraffin-embedded tissue that could be useful in diagnostic practice in the distinction between malignant mesothelioma and adenocarcinoma.
Karine Llinares; Fabienne Escande; Sébastien Aubert; Marie-Pierre Buisine; Carme de Bolos; Surinder K Batra; Bernard Gosselin; Jean-Pierre Aubert; Nicole Porchet; Marie-Christine Copin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc     Volume:  17     ISSN:  0893-3952     ISO Abbreviation:  Mod. Pathol.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-13     Completed Date:  2004-09-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8806605     Medline TA:  Mod Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  150-7     Citation Subset:  IM    
Unité INSERM U560 Laboratoire de Recherche Gérard Biserte, Place de Verdun, Lille, France.
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MeSH Terms
Adenocarcinoma / diagnosis*
Diagnosis, Differential
Gene Expression
In Situ Hybridization
Lung Neoplasms / diagnosis*
Mesothelioma / diagnosis*
Middle Aged
Mucins / biosynthesis*
Pleural Neoplasms / diagnosis*
Reverse Transcriptase Polymerase Chain Reaction
Tumor Markers, Biological / analysis*
Reg. No./Substance:
0/MUC4 protein, human; 0/Muc4 protein, rat; 0/Mucin-4; 0/Mucins; 0/Tumor Markers, Biological

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