Document Detail

Diagnostic value of FDG-PET and HMPAO-SPET in patients with mild dementia and mild cognitive impairment: metabolic index and perfusion index.
MedLine Citation:
PMID:  15908747     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The diagnostic potential of F-18-2-fluoro-2-deoxy-D-glucose positron emission tomography (PET) and technetium-99m hexamethylpropylene amine oxime single-photon emission tomography (SPET) in early detection and differential diagnosis of early dementia was evaluated including a comparison of metabolic and perfusion indices (PI). METHODS: Twenty-four patients with initial clinical suspicion of beginning dementia were examined, 12 of them with mild cognitive impairment. All patients underwent SPET and PET within 2 weeks. Data were compared with the final clinical diagnosis at follow-up - 9 with Alzheimer's disease (AD), 1 with frontotemporal dementia, 1 with vascular dementia (VD), 7 with mixed type of dementia (MIX) and 6 without any type of dementia. Metabolic indices (MI) and PI were compared with each other. The regional cerebral blood flow difference (rCBFdiff) calculated as local uptake difference between the right and left hemisphere was measured for patients with VD and MIX. RESULTS: PET showed higher sensitivity and specificity in identifying the different types of early dementia (44--91 and 78--89%, respectively) than SPET (11--64 and 79--89%, respectively), especially in detecting AD (sensitivity 44%, specificity 83%) and MIX (sensitivity 71%, specificity 78%). Especially in patients with mild cognitive impairment, PET was the superior imaging modality for predicting dementia. Using PET, dementia could be excluded in all patients who did not develop dementia during the follow-up. In all patients, a weak correlation between PI and MI was observed (rho=0.64, p<0.002). The rCBFdiff in patients with VD and MIX ranged from 7 to 37%. CONCLUSION: In this study on patients with initial suspicion of beginning dementia who underwent both imaging modalities, PET and SPET, PET was the superior imaging method, especially in the detection of early AD or MIX.
Natascha Döbert; Johannes Pantel; Lutz Frölich; Nadja Hamscho; Christian Menzel; Frank Grünwald
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Publication Detail:
Type:  Journal Article     Date:  2005-05-20
Journal Detail:
Title:  Dementia and geriatric cognitive disorders     Volume:  20     ISSN:  1420-8008     ISO Abbreviation:  Dement Geriatr Cogn Disord     Publication Date:  2005  
Date Detail:
Created Date:  2005-08-19     Completed Date:  2005-10-13     Revised Date:  2008-03-24    
Medline Journal Info:
Nlm Unique ID:  9705200     Medline TA:  Dement Geriatr Cogn Disord     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  63-70     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 S. Karger AG, Basel.
Department of Nuclear Medicine, University of Frankfurt, Frankfurt, Germany. Doebert@em,
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MeSH Terms
Brain / radionuclide imaging
Brain Chemistry
Cerebrovascular Circulation / physiology
Cognition Disorders / metabolism,  physiopathology,  radionuclide imaging*
Dementia / metabolism,  physiopathology,  radionuclide imaging*
Fluorodeoxyglucose F18 / diagnostic use
Glucose / metabolism
Neuropsychological Tests
Positron-Emission Tomography
Technetium Tc 99m Exametazime / diagnostic use
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
100504-35-6/Technetium Tc 99m Exametazime; 50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18

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