Document Detail


Diagnostic utility of a new monoclonal antibody pancreatic isoamylase assay in chronic pancreatic diseases.
MedLine Citation:
PMID:  2230667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to evaluate the efficacy of a monoclonal pancreatic (P) isoamylase assay in the diagnosis of chronic pancreatic disease and to compare the behavior of this test with that of amylase and elastase 1, these three enzymes were measured in the sera of 39 healthy controls, 28 patients with pancreatic cancer, 50 with chronic pancreatitis and 60 with extra-pancreatic diseases. In patients with chronic relapsing pancreatitis, increased P-isoamylase and elastase 1 values were found in similar percentages (about 70%), whereas the percentage for elevated amylase values was lower (52%). Elastase 1 was increased in 52% of patients with pancreatic cancer, while the other two enzymes were only occasionally elevated. The levels for all three enzymes were abnormal in some patients with extra-pancreatic diseases. It may be concluded that this assay for P-isoamylase determination is sufficiently sensitive and reliable in detecting pancreatic inflammation, even though some limitations concerning its specificity should be born in mind.
Authors:
M P Panozzo; D Basso; C Fabris; D Faggian; T Meggiato; M Plebani; G Del Favero; P Fogar; P Scalon; C Ferrara
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of clinical chemistry and clinical biochemistry. Zeitschrift für klinische Chemie und klinische Biochemie     Volume:  28     ISSN:  0340-076X     ISO Abbreviation:  J. Clin. Chem. Clin. Biochem.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-12-12     Completed Date:  1990-12-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7701860     Medline TA:  J Clin Chem Clin Biochem     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  485-8     Citation Subset:  IM    
Affiliation:
Istituto di Medicina Interna, Università degli Studi di Padova, Italia.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Antibodies, Monoclonal / diagnostic use*
Chronic Disease
Clinical Enzyme Tests
Female
Humans
Isoamylase / metabolism*
Male
Middle Aged
Pancreas / enzymology*
Pancreatic Diseases / diagnosis*,  enzymology
Pancreatic Elastase / metabolism
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; EC 3.2.1.68/Isoamylase; EC 3.4.21.36/Pancreatic Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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