| Diagnostic utility of cerebral white matter integrity in early Alzheimer's disease. | |
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MedLine Citation:
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PMID: 20615058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We compared white matter integrity with brain atrophy in healthy controls and participants with very mild dementia (Clinical Dementia Rating 0 vs. 0.5) from the Brain Aging Project, a longitudinal study of aging and memory at the University of Kansas Medical Center. Structural magnetic resonance imaging and diffusion tensor imaging (DTI) including fractional anisotropy and mean diffusivity were performed on 27 patients with very mild dementia (Clinical Dementia Rating = 0.5) of the Alzheimer's type (DAT), and 32 cognitively normal subjects. Patient groups were compared across 6 volumetric measures and 14 DTI regions of interest. Very mildly demented patients showed expected disease-related patterns of brain atrophy with reductions in whole-brain and hippocampal volumes most prominent. DTI indices of white matter integrity were mixed. Right parahippocampus showed significant but small disease-related reductions in fractional anisotropy. Right parahippocampus and left internal capsule showed greater mean diffusivity in early DAT compared with controls. A series of discriminant analyses demonstrated that gray matter atrophy was a significantly better predictor of dementia status than were DTI indices. Brain atrophy was most strongly related to very mild DAT. Modest disease-related white matter anomalies were present in temporal cortex, and deep white matter had limited discriminatory diagnostic power, probably because of the very mild stage of disease in these participants. |
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Authors:
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David K Johnson; Willis Barrow; Raeann Anderson; Amith Harsha; Robyn Honea; William M Brooks; Jeffrey M Burns |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The International journal of neuroscience Volume: 120 ISSN: 1563-5279 ISO Abbreviation: Int. J. Neurosci. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-09 Completed Date: 2010-10-21 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 0270707 Medline TA: Int J Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 544-50 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Kansas, Lawrence, KS 66045, USA. dkj@ku.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alzheimer Disease / complications, diagnosis* Anisotropy Brain Mapping Case-Control Studies Cerebral Cortex / pathology* Cognition Disorders / diagnosis*, etiology Cohort Studies Diffusion Magnetic Resonance Imaging / methods Female Hippocampus / pathology Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging / methods Male Nerve Fibers, Myelinated / pathology* Neuropsychological Tests Retrospective Studies |
| Grant Support | |
ID/Acronym/Agency:
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AG026482/AG/NIA NIH HHS; K23 NS058252-05/NS/NINDS NIH HHS; K23NS058252/NS/NINDS NIH HHS; M01RR023940/RR/NCRR NIH HHS; NS039123/NS/NINDS NIH HHS; R03 AG026374-01/AG/NIA NIH HHS; R03AG026374/AG/NIA NIH HHS; R21 AG029615-02/AG/NIA NIH HHS; R21AG029615/AG/NIA NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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