Document Detail


Diagnostic usefulness of serum interleukin 6 (IL-6) and C-reactive protein (CRP) in the differentiation between pancreatic cancer and chronic pancreatitis.
MedLine Citation:
PMID:  20626020     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previous studies have shown elevated serum levels of interleukin 6 (IL-6) and C-reactive protein (CRP) in patients with pancreatic cancer (PC). The aim of this study was to assess the diagnostic usefulness of pretreatment serum levels of IL-6 and CRP to differentiate between PC and chronic pancreatitis (CP) patients. Serum levels of CRP, IL-6, carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA 19-9) were determined in 78 patients with PC before surgery, in 45 patients with CP, and in 70 healthy controls. Serum levels of all the proteins tested were significantly higher in cancer patients when compared with CP and healthy subjects, and increased in more advanced tumor stages. Concentrations of IL-6 were significantly higher in nonresectable tumors and in patients who died during the 2-year observation period. Area under receiver operating characteristic curve for IL-6 was higher than for other substances tested in the differentiation between PC and CP. Cox's univariate analysis revealed serum IL-6 as a significant prognostic factor of patients' survival. Our findings suggest higher diagnostic usefulness of serum IL-6 than CRP, CEA, and CA 19-9 in the diagnosis and prognosis of patients with PC and in the differentiation with CP.
Authors:
Barbara Mroczko; Magdalena Groblewska; Mariusz Gryko; Bogusław Kedra; Maciej Szmitkowski
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical laboratory analysis     Volume:  24     ISSN:  1098-2825     ISO Abbreviation:  J. Clin. Lab. Anal.     Publication Date:  2010  
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801384     Medline TA:  J Clin Lab Anal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  256-61     Citation Subset:  IM    
Affiliation:
Department of Biochemical Diagnostics, Medical University, Białystok, Poland. mroczko@umwb.edu.pl
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Analysis of Variance
Area Under Curve
C-Reactive Protein / analysis*
CA-19-9 Antigen / blood
Carcinoembryonic Antigen / blood
Case-Control Studies
Diagnosis, Differential
Female
Humans
Interleukin-6 / blood*
Kaplan-Meier Estimate
Male
Middle Aged
Pancreatic Neoplasms / blood*,  diagnosis
Pancreatitis, Chronic / blood*,  diagnosis
Predictive Value of Tests
Chemical
Reg. No./Substance:
0/CA-19-9 Antigen; 0/Carcinoembryonic Antigen; 0/Interleukin-6; 9007-41-4/C-Reactive Protein

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