Document Detail


Diagnostic use of anti-modified nucleoside monoclonal antibody.
MedLine Citation:
PMID:  1306318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
By use of monoclonal antibodies (MoAbs) termed APU-6 and AMA-2, we determined the usefulness of urinary modified nucleosides, pseudouridine and 1-methyladenosine, as markers for malignancy. In patients with leukemia and other forms of cancer, these nucleosides elevated significantly and reflected the disease status of patients. The immunohistochemical analysis showed that cancer cells were specifically stained with the MoAbs. Chemical identification of the cellular components reactive with the MoAbs revealed that APU-6-associated antigens were mainly rRNA and AMA-2-associated antigens were mainly tRNA. These results suggest that APU-6 and AMA-2 would be useful tools for clinical and biological studies of cancer.
Authors:
K Itoh; S Ishiwata; N Ishida; M Mizugaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  168     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1993-08-05     Completed Date:  1993-08-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  329-31     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai.
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MeSH Terms
Descriptor/Qualifier:
Adenosine / analogs & derivatives*,  urine
Antibodies, Monoclonal / diagnostic use*
Antibody Specificity
Humans
Immunoenzyme Techniques
Leukemia / urine*
Lymphoma / urine*
Monitoring, Physiologic / methods
Pseudouridine / urine*
Tumor Markers, Biological / urine*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Tumor Markers, Biological; 1445-07-4/Pseudouridine; 15763-06-1/1-methyladenosine; 58-61-7/Adenosine

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