| Diagnostic use of angiotensin converting enzyme inhibitors in radioisotope evaluation of unilateral renal artery stenosis. | |
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MedLine Citation:
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PMID: 2541228 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Iodine-123 hippurate renography, [99mTc]diethylenetriaminepentaacetic acid (DTPA) renography, and [99mTc]dimercapto succinic acid (DMSA) renal scintigraphy were performed before and during angiotensin converting enzyme (ACE) inhibition in a group of 15 hypertensive patients with angiographically "significant" unilateral renal artery stenosis. Visual and quantitative evaluation of the three radioisotope methods before ACE inhibition already disclosed abnormalities suggestive of renal artery stenosis in a high percentage (87%, 60%, and 60%, respectively) in this group of patients, but ACE inhibition further improved the diagnostic yield in all three methods (93%, 86%, and 80%). Iodine-123 hippurate renography was at least as useful as [99mTc]DTPA renography in this respect, while [99mTc]DMSA scintigraphy can be used particularly in segmental stenosis. Despite a large drop in blood pressure after ACE inhibition little adverse reactions were seen and overall renal function was fairly well maintained, the exceptions noted in patients with initially a more impaired renal function. |
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Authors:
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T K Kremer Hovinga; P E de Jong; D A Piers; H Beekhuis; G K van der Hem; D de Zeeuw |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 30 ISSN: 0161-5505 ISO Abbreviation: J. Nucl. Med. Publication Date: 1989 May |
Date Detail:
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Created Date: 1989-06-22 Completed Date: 1989-06-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 605-14 Citation Subset: IM |
Affiliation:
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Department of Nephrology, University Hospital, Groningen, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Angiotensin-Converting Enzyme Inhibitors / diagnostic use* Blood Pressure / drug effects Drug Evaluation Enalapril / diagnostic use Female Humans Hypertension, Renovascular / physiopathology, radionuclide imaging Iodohippuric Acid / diagnostic use Kidney / radionuclide imaging Male Middle Aged Organometallic Compounds / diagnostic use Pentetic Acid / diagnostic use Renal Artery Obstruction / physiopathology, radionuclide imaging* Succimer / diagnostic use Technetium / diagnostic use Technetium Tc 99m Dimercaptosuccinic Acid Technetium Tc 99m Pentetate |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Organometallic Compounds; 147-58-0/Iodohippuric Acid; 304-55-2/Succimer; 65438-08-6/Technetium Tc 99m Dimercaptosuccinic Acid; 65454-61-7/Technetium Tc 99m Pentetate; 67-43-6/Pentetic Acid; 7440-26-8/Technetium; 75847-73-3/Enalapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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