Document Detail

Diagnostic ultrasound combined with targeted microbubbles improves recovery following acute coronary thrombosis.
MedLine Citation:
PMID:  19355405     Owner:  NLM     Status:  In-Data-Review    
Forty-five pigs with acute coronary artery occlusions-low MI pulse sequence (CPS) to guide high MI (1.9 MI) pulses during infusion of platelet-targeted MBs or non-targeted MBs. Third group received no ultrasoundMB. All groups received pro-urokinase, heparin, and aspirin. Angiographic recanalization rates, resolution of ST elevation, and wall thickening were analyzed. Pigs receiving MB had more rapid replenishment of risk area (RA) (80% versus 40% for MB; p=0.03) and higher epicardial recanalization rates (53% versus 7% for pro-urokinase alone; p=0.01). Replenishment of contrast within RA with MB showed higher recanalization rates and higher rates of ST resolution (82% versus 21% for pro-urokinase alone; p=0.006). ST resolution occurred in six pigs (40%) with MB who did not have epicardial recanalization; five had recovery of wall thickening. Conclusions: IV MB with brief high MI DUS guided by CPS improves both epicardial recanalization rates and microvascular recovery.
Evan Unger; Terry Matsunaga; Feng Xie; Thomas Porter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of the Acoustical Society of America     Volume:  125     ISSN:  1520-8524     ISO Abbreviation:  J. Acoust. Soc. Am.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503051     Medline TA:  J Acoust Soc Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2713     Citation Subset:  IM    
Dept. of Radiology, Univ. of Arizona, 1501 N. Campbell Ave., Tucson, AZ 85724Univ. of Nebraska Medical Ctr., Omaha, NE 68198.
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