| Diagnostic transcranial ultrasound perfusion-imaging at 2.5 MHz does not affect the blood-brain barrier. | |
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MedLine Citation:
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PMID: 17854981 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose was to assess whether standard ultrasound (US) perfusion-imaging by means of contrast-enhanced transcranial color-coded sonography (TCCS) affects the blood-brain barrier (BBB) in patients with small-vessel disease (SVD). One week after a screening MRI to exclude a preexisting BBB disruption, unilateral TCCS phase inversion harmonic imaging (PIHI) was performed in an axial diencephalic plane after intravenous bolus application of 2.5 mL SonoVue (IGEA, Bracco, Italy). Magnetic resonance imaging (MRI) was performed immediately after US. In five patients, PIHI was performed applying a mean mechanical index (MI) of 0.7 +/- 0.1 for a time period of 2.5 min. MRI was started 12 +/- 2 min after US contrast injection. Comparisons of initial and post-US MRI by four blinded readers did not show any signs of BBB disruption. It is concluded that standard contrast-enhanced US perfusion imaging in patients with SVD did not lead to MRI-detectable BBB changes. This gives further evidence for safety of diagnostic US. Future investigations with larger sample sizes and higher-field MRI might give further insights into potential bioeffects of diagnostic, as well as therapeutic, contrast-enhanced transcranial US. |
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Authors:
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Gerhard J Jungehulsing; Peter Brunecker; Christian H Nolte; Jochen B Fiebach; Claudia Kunze; Florian Doepp; Arno Villringer; Stephan J Schreiber |
Publication Detail:
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Type: Journal Article Date: 2007-09-14 |
Journal Detail:
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Title: Ultrasound in medicine & biology Volume: 34 ISSN: 0301-5629 ISO Abbreviation: Ultrasound Med Biol Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-18 Completed Date: 2008-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 147-50 Citation Subset: IM |
Affiliation:
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Department of Neurology and Berlin Neuroimaging Center Berlin, Charité, Germany. jan.jungehuelsing@charite.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood-Brain Barrier* Cerebral Infarction / physiopathology, ultrasonography* Contrast Media Humans Magnetic Resonance Imaging Middle Aged Phospholipids / diagnostic use Sulfur Hexafluoride / diagnostic use Thalamus / blood supply Time Factors Ultrasonography, Doppler, Color / adverse effects, methods Ultrasonography, Doppler, Transcranial / adverse effects*, methods |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Phospholipids; 0/contrast agent BR1; 2551-62-4/Sulfur Hexafluoride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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