| Diagnostic and therapeutic value of airway challenges in asthma. | |
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MedLine Citation:
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PMID: 19348726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Airway challenges are of value in the assessment of asthma. Direct challenges (histamine and methacholine) are highly sensitive for clinically current symptomatic asthma and particularly useful to exclude current asthma when they are negative. Indirect challenges (exercise, eucapnic voluntary hyperventilation, adenosine monophosphate, hypertonic saline, mannitol) are more specific but very insensitive for clinical asthma. They are of particular value to confirm asthma and to differentiate asthma from other airway diseases, such as chronic airflow limitation. The indirect stimuli are the challenges of choice for evaluating exercise-induced bronchoconstriction. |
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Authors:
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Donald W Cockcroft; Beth E Davis |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current allergy and asthma reports Volume: 9 ISSN: 1534-6315 ISO Abbreviation: Curr Allergy Asthma Rep Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-07 Completed Date: 2009-06-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101096440 Medline TA: Curr Allergy Asthma Rep Country: United States |
Other Details:
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Languages: eng Pagination: 247-53 Citation Subset: IM |
Affiliation:
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Division of Respirology, Critical Care, and Sleep Medicine, Royal University Hospital, 103 Hospital Drive, Ellis Hall, 5th Floor, Saskatoon, Saskatchewan S7N0W8, Canada. don.cockcroft@usask.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Monophosphate
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diagnostic use Asthma / diagnosis*, physiopathology, therapy* Bronchi / physiopathology Bronchial Hyperreactivity / physiopathology* Bronchial Provocation Tests Bronchoconstrictor Agents / diagnostic use* Humans Mannitol / diagnostic use Methacholine Chloride / diagnostic use* Saline Solution, Hypertonic / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Bronchoconstrictor Agents; 0/Saline Solution, Hypertonic; 61-19-8/Adenosine Monophosphate; 62-51-1/Methacholine Chloride; 69-65-8/Mannitol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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