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Diagnostic and therapeutic challenges of intracranial hemorrhage in neonates with congenital hemophilia: a case report and review.
MedLine Citation:
PMID:  23049462     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Intracranial hemorrhage (ICH) in full-term neonates with hemophilia is uncommon. Retrospective studies estimate the incidence to be 3.4%-4.0%. However, ICH is the second most common initial hemorrhage for all infants with congenital hemophilia. Nearly half (41%) of the hemorrhages occur within the first week of life, and most hemorrhages are related to traumatic deliveries. But clinical signs of ICH in neonates are difficult to assess and often result in a delay in the diagnosis. The timely diagnosis of ICH is critical; however, the early and intensive factor replacement therapy that the patient needs is associated with the risk of inhibitor formation. We report a case of ICH in a neonate with severe hemophilia A, no family history, and inhibitor development after intensive therapy.
Authors:
Tammuella Chrisentery Singleton; Matthew Keane
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Ochsner journal     Volume:  12     ISSN:  1524-5012     ISO Abbreviation:  Ochsner J     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-10     Completed Date:  2012-10-11     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101125795     Medline TA:  Ochsner J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  249-53     Citation Subset:  -    
Affiliation:
Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA ; The Louisiana Center for Bleeding and Clotting Disorders, New Orleans, LA.
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