Document Detail

Diagnostic terminology for urinary cytology reports including the new subcategories 'atypical urothelial cells of undetermined significance' (AUC-US) and 'cannot exclude high grade' (AUC-H).
MedLine Citation:
PMID:  23461719     Owner:  NLM     Status:  Publisher    
OBJECTIVE: We studied whether atypical, non-superficial urothelial cells (AUC) could be separated into new subcategories including AUC 'of undetermined significance' (AUC-US) and 'cannot exclude high grade'' (AUC-H) in order to help to standardize urine cytopathology reports, as it is widely accepted in the Bethesda system for gynaecological cytopathology. METHODS: We investigated whether AUC-US and AUC-H, defined by distinctive cytological criteria, might be separated with statistical significance according to actual diagnosis and follow-up data. A series of 534 cyto-histological comparisons taken in 139 patients, including 221 AUC at various steps of their clinical history was studied. There were 513 (96.1%) postcystoscopy and 469 (87.8%) ThinPrep® liquid-based specimens (95.9% and 89.1% of AUC cases, respectively). Patients viewed between 1999 and 2011 had histological control in a 0- to 6-months delay and were followed-up during an additional 5.9 ± 9.2 (0- to 56-) months period. RESULTS: The 221 AUC represented 0.8-2% of the specimens viewed during the study period. Among AUC-H cases, 70 out of 185 (37.8%) matched with high-grade lesions, compared with 3 of 38 (8.3%) of AUC-US cases (P = 0.0003). Conservatively treated patients with AUC-H more frequently developed high-grade lesions than those with AUC-US (54.1% versus 16.7%, P = 0.0007) with a 17.6-months mean delay. Nuclear hyperchromasia, a nuclear to cytoplasm (N/C) ratio > 0.7 and the combination of both were the more informative diagnostic criteria, all with P < 0.01. CONCLUSION: We conclude that the new subcategories could help to standardize urine cytopathology reports and contribute to the patient's management, provided it is validated by multicentric studies.
E Piaton; M Decaussin-Petrucci; F Mege-Lechevallier; A-S Advenier; M Devonec; A Ruffion
Related Documents :
23358339 - Consideration of algorithms to presume the lesion location by using x-ray images of the...
575679 - Adiaspiromycosis of human skin caused by emmonsia crescens.
24799949 - Utility of molecular tests in cytopathology.
16121049 - The capillary lobule: a deceptively benign feature of post-radiation angiosarcoma of th...
9692309 - A case of hydroa vacciniforme with unusual ear mutilation.
23676809 - The diagnostic value of fine needle aspiration in parotid lumps.
21332699 - Early melanoma with halo eczema (meyerson's phenomenon).
25015139 - Gross examination.
19121879 - Ultrasound-guided core biopsy for investigation of cervical lymph node: chronic lymphoc...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-3-5
Journal Detail:
Title:  Cytopathology : official journal of the British Society for Clinical Cytology     Volume:  -     ISSN:  1365-2303     ISO Abbreviation:  Cytopathology     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010345     Medline TA:  Cytopathology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Blackwell Publishing Ltd.
Hospices Civils de Lyon, Centre de Pathologie Est, Hôpital Femme-Mère-Enfant, Bron, France; Université Claude Bernard Lyon 1, Lyon, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  News from the Biological Stain Commission No. 14.
Next Document:  A GPR18-based signaling system regulates IOP in murine eye.