Document Detail


Diagnostic significance of indium-111 granulocyte scintigraphy in febrile patients.
MedLine Citation:
PMID:  3806219     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sixty-eight patients with fever of unknown origin, 32 patients with postoperative fever, and 26 patients with therapy-resistant fever after bacteremia were investigated with [111In] granulocyte scintigraphy for the detection of abscesses. The results showed that the value of [111In]granulocyte scintigraphy in the detection of infectious foci vary in these three types of febrile conditions. The overall sensitivity and specificity were 86.5% and 87.8%, respectively. We observed, however, a relatively low predictive value of a positive result in the fever of unknown origin group (73.1%), and also a low predictive value of a negative result in the bacteremia group (66.7%). The C-reactive protein (CRP) levels in patients with a true-positive scintigram were significantly (p less than 0.001) higher than in patients with a true-negative scintigram. There was also a significant positive correlation (p less than 0.01) between the serum CRP concentration and the intensity of the granulocyte accumulations. There was no correlation between the peripheral leukocyte count or the erythrocyte sedimentation rate (ESR) and the intensity of the granulocyte uptake. Therefore CRP, but not the leukocyte count or ESR, appears useful for selecting the patients who benefit most from granulocyte scintigraphy.
Authors:
M T Syrjälä; V Valtonen; K Liewendahl; G Myllylä
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  28     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-02-26     Completed Date:  1987-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  155-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Bacterial Infections / radionuclide imaging*
Blood Sedimentation
C-Reactive Protein / analysis
Female
Fever / etiology,  radionuclide imaging*
Fever of Unknown Origin / radionuclide imaging
Granulocytes*
Humans
Indium / diagnostic use*
Leukocyte Count
Male
Middle Aged
Postoperative Complications / radionuclide imaging
Predictive Value of Tests
Radioisotopes / diagnostic use*
Sepsis / radionuclide imaging
Chemical
Reg. No./Substance:
0/Radioisotopes; 7440-74-6/Indium; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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