| Diagnostic significance of antibody to native deoxyribonucleic acid in children with juvenile rheumatoid arthritis and other connective tissue diseases. | |
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MedLine Citation:
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PMID: 690754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sera of children with juvenile rheumatoid arthritis and other connective tissue diseases were tested for antibodies to native DNA by a radiolabeled-binding assay. Normal values were obtained in 130 children with JRA, including 28 with uveitis and 14 with selective IgA deficiency. Normal values were also found in sera from children with dermatomyositis, scleroderma, polyarteritis, ankylosing spondylitis, and a variety of other nonconnective tissue diseases. The only sera with elevated DNA-binding assays were from children with systemic lupus erythematosus. On the basis of these data, increased levels of antibodies to native DNA distinguished patients with active SLE from children with JRA. |
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Authors:
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J T Cassidy; S E Walker; S J Soderstrom; R E Petty; D B Sullivan |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of pediatrics Volume: 93 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1978 Sep |
Date Detail:
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Created Date: 1978-11-18 Completed Date: 1978-11-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 416-20 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Arthritis, Juvenile Rheumatoid / diagnosis, immunology* Autoantibodies / analysis*, metabolism Child DNA / immunology*, metabolism Diagnosis, Differential Female Humans Lupus Erythematosus, Systemic / diagnosis, immunology* Male |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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