| Diagnostic sensitivity of hepatocellular carcinoma imaging and its application to non-cirrhotic patients. | |
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MedLine Citation:
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PMID: 21418303 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background and Aims: The American Association for the Study of Liver Disease issued guidelines that proposed that hepatocellular carcinoma (HCC) can be diagnosed if a mass is larger than 2 cm in a cirrhotic liver and shows typical features of HCC at triphasic liver computed tomography (CT) or dynamic magnetic resonance imaging (MRI). In non-cirrhotic livers, the criteria were not applicable. The aim of the present study was to retrospectively analyze the sensitivity of imaging by samples of definite HCC postoperatively and test their application to diagnose HCC in non-cirrhotic livers. Methods: From January 2006 to November 2008, a total of 343 pathologically-diagnosed HCC patients via surgical resection were reviewed. Among the 343 patients, 204 patients had undergone liver CT examination, and 80 patients underwent MRI examination; serum α-fetoprotein had been checked for all 343 patients prior to operation. The diagnostic sensitivity of HCC by imaging was evaluated and compared in patients with/without cirrhosis by ultrasound and histology. Results: The diagnostic sensitivity of HCC by single imaging was approximately 65-80% (liver CT or MRI). A higher sensitivity of HCC diagnosis was found in patients with ultrasound-diagnosed cirrhosis than non-cirrhosis, but the difference in sensitivity disappeared after histologically-cirrhotic validation. The results indicated that regardless of the presence or absence of cirrhosis (histology), a typical vascular pattern could diagnose HCC with equally high sensitivity. Conclusions: We provide evidence that the sensitivity of HCC diagnosis by imaging is not influenced by the cirrhotic background. Further study is needed to validate the specificity and accuracy. |
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Authors:
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Ming-Tzung Lin; Chao-Long Chen; Chih-Chi Wang; Yu-Fan Cheng; Hock-Liew Eng; Jing-Houng Wang; King-Wah Chiu; Chuan-Mo Lee; Tsung-Hui Hu |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Journal of gastroenterology and hepatology Volume: 26 ISSN: 1440-1746 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: - |
Other Details:
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Languages: ENG Pagination: 745-750 Citation Subset: - |
Copyright Information:
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© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
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Department of Internal Medicine, Chang Gang Memorial Hospital-Kaohsiung Medical Center Chang Gang University College of Medicine, Kaohsiung, Taiwan Department of Surgery, Chang Gang Memorial Hospital-Kaohsiung Medical Center Chang Gang University College of Medicine, Kaohsiung, Taiwan Department of Radiology, Chang Gang Memorial Hospital-Kaohsiung Medical Center Chang Gang University College of Medicine, Kaohsiung, Taiwan Department of Pathology, Chang Gang Memorial Hospital-Kaohsiung Medical Center Chang Gang University College of Medicine, Kaohsiung, Taiwan. |
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