Document Detail

Diagnostic scoring system of Hirschsprung's disease in the neonatal period.
MedLine Citation:
PMID:  16877220     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Eighty to ninety percent of Hirschsprung's disease (HD) patients present in newborns. However, the diagnosis of HD in the neonatal period remains difficult. Our present study aims to propose a diagnostic scoring system and hope this will increase early diagnosis of HD and avoid unnecessary rectal biopsy. METHODS: In the first study period, 57 suspected HD patients (0-3 months) completed our predetermined study protocol in which barium enema (BE), rectal manometry (RM) and full-thickness rectal biopsy were performed. Symptoms, signs and investigations were analysed for their correlation with HD diagnosis. A HD diagnostic scoring system was developed according to the statistical results and was assessed in 74 patients in the second study period. RESULTS: Forty-five patients were diagnosed with HD in the first study period. A HD scoring system was developed in which delayed meconium, tight anus, BE and RM were diagnostic factors. A cut-off point of 3 provided 84% of HD patients score >3, whereas 75% non-HD patients score <or=3 (p < 0.05). In the second study group, patients with score <or=3 were selected for rectal biopsy. CONCLUSION: In the neonatal period, using a HD scoring system may help to select patients for further invasive investigation so that unnecessary biopsy can be avoided.
Weihong Guo; Qinming Zhang; Yongwei Chen; Dawei Hou
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian journal of surgery / Asian Surgical Association     Volume:  29     ISSN:  1015-9584     ISO Abbreviation:  Asian J Surg     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-31     Completed Date:  2006-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8900600     Medline TA:  Asian J Surg     Country:  China    
Other Details:
Languages:  eng     Pagination:  176-9     Citation Subset:  IM    
Department of Surgery, Beijing Children's Hospital Affiliated to Capital University of Medical Sciences, Xi Chi District, Beijing, China.
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MeSH Terms
Early Diagnosis
Hirschsprung Disease / complications*,  diagnosis*
Infant, Newborn
Sensitivity and Specificity

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