Document Detail


Diagnostic and prognostic value of Ki67 proliferation fraction in serous effusions.
MedLine Citation:
PMID:  15371657     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Ki67 proliferation rate of mesothelial cells was determined in 20 effusions due to malignant mesotheliomas and in 20 non-neoplastic effusions, to investigate if this marker may be useful to identify neoplastic mesothelioma cells and if there is a correlation between proliferation rate and survival time. Using the ABC-method, effusions were immunostained and the marker Ki67 was evaluated quantitatively. Ki67 proliferation fraction showed rates from 2.3% to 70% in malignant mesothelioma cells and from 1.8% to 25.5% in reactive mesothelial cells. A significant difference was found (p=0.05) between those two groups. Assuming a threshold at 26%, a sensitivity of 25% and specificity of 100% resulted. Yet, due to its low sensitivity this marker seems not to be useful for differential diagnosis. Plotting surviving period against Ki67 proliferation fraction a correlation was observed which was not significant. Long term survivors (>28 month) showed proliferation rates below 3.8%. Unexpectedly a highly significant difference (p=0.001) between Ki67 proliferation rates of mesothelial cells from patients with malignant tumors other than mesothelial origin (7.0% to 25.5%) and mesothelial cells of patients without any malignant disease (1.8% to 16.3%) were observed. Setting a threshold at 10% for identification of a malignant disease, a sensitivity of 77.8% and specificity of 90.9% resulted.
Authors:
Alexandra Schönherr; Mary Bayer; Alfred Böcking
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cellular oncology : the official journal of the International Society for Cellular Oncology     Volume:  26     ISSN:  1570-5870     ISO Abbreviation:  Cell. Oncol.     Publication Date:  2004  
Date Detail:
Created Date:  2004-09-16     Completed Date:  2005-03-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101219418     Medline TA:  Cell Oncol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  57-62     Citation Subset:  IM    
Affiliation:
Institute of Cytopathology, Heinrich Heine University, D-40225 Düsseldorf, Germany.
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MeSH Terms
Descriptor/Qualifier:
Ascitic Fluid / metabolism,  pathology*
Cell Proliferation
Epithelium / metabolism,  pathology
Female
Humans
Immunohistochemistry
Ki-67 Antigen* / metabolism
Male
Mesothelioma / diagnosis,  metabolism
Neoplasms / diagnosis*,  metabolism,  pathology
Pleural Effusion, Malignant / diagnosis*,  metabolism,  pathology
Predictive Value of Tests
Prognosis
Regression Analysis
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Ki-67 Antigen

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