Document Detail


Diagnostic and predictive factors of significant liver fibrosis and minimal lesions in patients with persistent unexplained elevated transaminases. A prospective multicenter study.
MedLine Citation:
PMID:  16837098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: In patients with unexplained elevated transaminases, prognosis of the liver disease and factors associated with increased risk of liver fibrosis and normal/subnormal liver are unknown. The aim of this prospective study was to identify diagnosis and clinical and biological factors associated with significant (bridging) fibrosis and minimal lesions of the liver in patients with persistent unexplained elevated ALT levels. METHODS: From July 2002 through October 2004, all consecutive asymptomatic patients with unexplained chronically elevated ALT levels were included. All patients had clinical, biological, ultrasonographic examination and a liver biopsy. RESULTS: 272 patients (60.3% males, mean age 46.4 years, BMI 26.7) were included. Pathological findings were: minimal lesions (18.7%), steatosis (26.8%), NASH (32.7%), and miscellaneous (21.7%). Significant fibrosis was found in 27.4% of cases, including 9 cases of cirrhosis. By multivariate analysis, independent predictors of significant fibrosis were tobacco use (OR 2.5, 95% CI 1.34-4.74 p=0.04), BMI>25 (2.49, 1.31-4.73 p=0.005) and diabetes (4.41, 1.73-11.29 p=0.002). Independent factors associated with minimal lesions were female gender (OR 3.4 95% CI 1.73-6.75 p<0.0001) and BMI<25 (3.55, 1.8-6.98, p<0.0001). CONCLUSIONS: In patients with unexplained chronically elevated transaminases, significant fibrosis is statistically associated with tobacco use, BMI>25 and diabetes, and minimal lesions are significantly associated with female gender and BMI<25.
Authors:
Victor de Lédinghen; Vlad Ratziu; Xavier Causse; Brigitte Le Bail; Dominique Capron; Christophe Renou; Christophe Pilette; Valérie Oules; Eve Gelsi; Frédéric Oberti; Anaïs Vallet-Pichard; Nicolas Le Provost; Jean-François Cadranel; ;
Related Documents :
538408 - Serum ethanol estimations in the control of alcohol abstinence in patients with liver d...
8847998 - Accumulation of manganese and copper in pallidum of cirrhotic patients: role in the pat...
4012608 - Prediction of operative cholangiography in patients undergoing elective cholecystectomy...
16716848 - Safety, efficacy, and tolerability of nelfinavir-containing antiretroviral therapy for ...
2120968 - Radiologic evaluation of esophageal motility: results in 170 patients with chest pain.
18612928 - The presence of anti-centromere antibodies may predict progression of estimated pulmona...
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2006-06-16
Journal Detail:
Title:  Journal of hepatology     Volume:  45     ISSN:  0168-8278     ISO Abbreviation:  J. Hepatol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-05     Completed Date:  2006-11-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  592-9     Citation Subset:  IM    
Affiliation:
Service d'Hépato-Gastroentérologie, Hôpital du Haut-Lévêque, Pessac, France. victor.deledinghen@chu-bordeaux.fr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Alanine Transaminase / blood*
Biopsy
Fatty Liver / blood,  pathology,  ultrasonography
Female
Humans
Liver / enzymology,  pathology
Liver Cirrhosis / blood*,  pathology,  ultrasonography*
Male
Middle Aged
Predictive Value of Tests
Prospective Studies
Severity of Illness Index*
gamma-Glutamyltransferase / blood*
Chemical
Reg. No./Substance:
EC 2.3.2.2/gamma-Glutamyltransferase; EC 2.6.1.2/Alanine Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Maternal third trimester hyperglycaemic excursions predict large-for-gestational-age infants in type...
Next Document:  In vivo selection of transduced hematopoietic stem cells and little evidence of their conversion int...