| Diagnostic performance of spectroscopic and perfusion MRI for distinction of brain tumors. | |
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MedLine Citation:
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PMID: 16801657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the value of spectroscopic and perfusion MRI for glioma grading and for distinguishing glioblastomas from metastases and from CNS lymphomas. METHODS: The authors examined 79 consecutive patients with first detection of a brain neoplasm on nonenhanced CT scans and no therapy prior to evaluation. Spectroscopic MRI; arterial spin-labeling MRI for measuring cerebral blood flow (CBF); first-pass dynamic, susceptibility-weighted, contrast-enhanced MRI for measuring cerebral blood volume; and T1-weighted dynamic contrast-enhanced MRI were performed. Receiver operating characteristic analysis was performed, and optimum thresholds for tumor classification and glioma grading were determined. RESULTS: Perfusion MRI had a higher diagnostic performance than spectroscopic MRI. Because of a significantly higher tumor blood flow in glioblastomas compared with CNS lymphomas, a threshold value of 1.2 for CBF provided sensitivity of 97%, specificity of 80%, positive predictive value (PPV) of 94%, and negative predictive value (NPV) of 89%. Because CBF was significantly higher in peritumoral nonenhancing T2-hyperintense regions of glioblastomas compared with metastases, a threshold value of 0.5 for CBF provided sensitivity, specificity, PPV, and NPV of 100%, 71%, 94%, and 100%. Glioblastomas had the highest tumor blood flow values among all other glioma grades. For discrimination of glioblastomas from grade 3 gliomas, sensitivity was 97%, specificity was 50%, PPV was 84%, and NPV was 86% (CBF threshold value of 1.4), and for discrimination of glioblastomas from grade 2 gliomas, sensitivity was 94%, specificity was 78%, PPV was 94%, and NPV was 78% (CBF threshold value of 1.6). CONCLUSION: Perfusion MRI is predictive in distinguishing glioblastomas from metastases, CNS lymphomas and other gliomas vs MRI and magnetic resonance spectroscopy. |
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Authors:
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M A Weber; S Zoubaa; M Schlieter; E Jüttler; H B Huttner; K Geletneky; C Ittrich; M P Lichy; A Kroll; J Debus; F L Giesel; M Hartmann; M Essig |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Neurology Volume: 66 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-27 Completed Date: 2006-07-19 Revised Date: 2006-09-28 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 1899-906 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany. m.a.weber@dkfz.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain Neoplasms
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classification*,
diagnosis* Diagnosis, Differential Female Humans Magnetic Resonance Imaging / methods* Magnetic Resonance Spectroscopy / methods* Male Middle Aged Perfusion Reproducibility of Results Sensitivity and Specificity |
| Comments/Corrections | |
Erratum In:
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Neurology. 2006 Sep 12;67(5):920 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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