Document Detail

Diagnostic performance of positron emission tomography using ¹¹C-methionine in patients with suspected parathyroid adenoma: a meta-analysis.
MedLine Citation:
PMID:  22801990     Owner:  NLM     Status:  MEDLINE    
The diagnostic performance of positron emission tomography using ¹¹C-methionine (MET-PET) in detecting parathyroid adenoma has been investigated by several studies with conflicting results. Aim of our study is to meta-analyze published data about this topic. A comprehensive computer literature search of studies published in PubMed/MEDLINE, Scopus and Embase databases through May 2012 and regarding the diagnostic performance of MET-PET in patients with parathyroid adenoma was carried out. No language restriction was used. Only articles in which at least five patients with parathyroid adenoma underwent MET-PET were included in the meta-analysis. Pooled sensitivity and detection rate (DR) on a per patient-based analysis were calculated to assess the diagnostic performance of MET-PET. Nine studies comprising 258 patients with suspected parathyroid adenoma were included in this meta-analysis. Pooled sensitivity and DR values of MET-PET in patients with suspected parathyroid adenoma were 81 % (95 % confidence interval [95 %CI] 74-86 %) and 70 % (95 %CI 62-77 %), respectively, on a per patient-based analysis. The included studies were heterogeneous in their estimate of sensitivity and DR. Our meta-analysis demonstrates that MET-PET is a sensitive and reliable tool in patients with suspected parathyroid adenoma. Thus, this imaging method could be helpful in patients with diagnosis of primary hyperparathyroidism when conventional imaging techniques are negative or inconclusive in localizing parathyroid adenoma.
Carmelo Caldarella; Giorgio Treglia; Maria Antonietta Isgrò; Alessandro Giordano
Publication Detail:
Type:  Journal Article; Meta-Analysis     Date:  2012-07-18
Journal Detail:
Title:  Endocrine     Volume:  43     ISSN:  1559-0100     ISO Abbreviation:  Endocrine     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-04     Completed Date:  2013-06-10     Revised Date:  2013-09-25    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  78-83     Citation Subset:  IM    
Institute of Nuclear Medicine, Department of Bioimaging and Radiological Sciences, Università Cattolica del Sacro Cuore, Largo Agostino Gemelli 8, 00168, Rome, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenoma / diagnosis*
Carbon Radioisotopes / diagnostic use
Evidence-Based Medicine*
Methionine / diagnostic use*
Parathyroid Neoplasms / diagnosis*
Positron-Emission Tomography
Sensitivity and Specificity
Reg. No./Substance:
0/Carbon Radioisotopes; 63-68-3/Methionine
Comment In:
Endocrine. 2013 Apr;43(2):251-2   [PMID:  23377756 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The influence of membrane bound proteins on phase separation and coarsening in cell membranes.
Next Document:  Early laparoscopic cholecystectomy for mild gallstone pancreatitis: time for a paradigm shift.