| Diagnostic performance of mid-regional pro-adrenomedullin as an analyte for the exclusion of left ventricular dysfunction. | |
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MedLine Citation:
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PMID: 17698224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: In ambulatory patients with coronary artery disease (CAD) we aimed to evaluate the diagnostic performance of mid-regional pro-adrenomedullin (MR-proADM) for the detection or exclusion of impaired left ventricular ejection fraction (LVEF). METHODS AND RESULTS: MR-proADM levels were measured in blood samples taken from 102 outpatients with CAD classified according to the New York Heart Association (NYHA) and Canadian Cardiovascular society (CCS) I-II. Increased levels of MR-proADM correlated with impaired LVEF (r=-0.21, p=0.046). The optimal threshold of MR-proADM for identification of impaired LVEF <50% was 0.54 nmol/L with an area under the ROC curve (AUC) of 0.64 (p=0.06). In univariate and multivariate calculation, MR-proADM >0.54 nmol/L remained associated with left ventricular dysfunction even after adjusting for age and gender. The negative predictive value (NPV) for MR-proADM <or=0.54 nmol/L was 88%, the specificity was 66%. CONCLUSIONS: We showed that MR-proADM is related to impaired LVEF. With an NPV of 88% MR-proADM might be a supportive tool to exclude negatively tested outpatients with CAD from further LVEF-diagnosis with moderate reliability. |
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Authors:
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Elif Elmas; Siegfried Lang; Carl Erik Dempfle; Thorsten Kälsch; Jana Papassotiriou; Nils G Morgenthaler; Martin Borggrefe; Martina Brueckmann |
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Publication Detail:
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Type: Letter Date: 2007-08-14 |
Journal Detail:
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Title: International journal of cardiology Volume: 128 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-08 Completed Date: 2008-09-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 107-11 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenomedullin
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blood* Area Under Curve Biological Markers / blood Diagnosis, Differential Female Humans Male Middle Aged Predictive Value of Tests Protein Precursors / blood* ROC Curve Risk Factors Sensitivity and Specificity Ventricular Dysfunction, Left / diagnosis* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Protein Precursors; 0/proadrenomedullin; 148498-78-6/Adrenomedullin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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