Document Detail

Diagnostic oral food challenges: procedures and biomarkers.
MedLine Citation:
PMID:  22414488     Owner:  NLM     Status:  MEDLINE    
Oral food challenge (OFC) is the gold standard for the diagnosis of food allergy. They are conducted to confirm whether an allergy to food exists (initial challenge) or to monitor for resolution of a food allergy. The history of an immediate allergic reaction, when supported by positive tests for specific IgE antibodies to the suspect food, is often sufficient to establish a diagnosis without OFC. Additionally, higher concentrations of food-specific IgE or larger allergy prick skin test wheal sizes correlate with an increased likelihood of a reaction upon ingestion. Although these food-specific IgE tests are helpful biomarkers of allergy, their limited sensitivity and specificity often necessitates the use of OFC to establish reactivity. Furthermore, the pathogenesis of non-IgE-mediated food allergy, such as food protein-induced enterocolitis (FPIES) or proctocolitis and food allergy due to mixed IgE and non-IgE mediated processes, such as atopic dermatitis or eosinophilic gastroenteropathies may not be assessable with specific IgE tests, also warranting OFCs. This review provides an overview on the technique and interpretation of OFCs, use of food-specific testing to predict whether OFC is warranted and to predict OFC outcomes. Additionally, biomarkers that correlate with OFC outcomes will be discussed, as well as future diagnostic tests promising better predictive value.
Kirsi M Järvinen; Scott H Sicherer
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Publication Detail:
Type:  Journal Article     Date:  2012-03-04
Journal Detail:
Title:  Journal of immunological methods     Volume:  383     ISSN:  1872-7905     ISO Abbreviation:  J. Immunol. Methods     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-03     Completed Date:  2012-10-12     Revised Date:  2013-07-09    
Medline Journal Info:
Nlm Unique ID:  1305440     Medline TA:  J Immunol Methods     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  30-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Albany Medical College, Division of Allergy and Immunology & Center for Immunology and Microbial Diseases, 47 New Scotland Ave, MC #151, Albany, NY 12208, United States.
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MeSH Terms
Allergens / immunology*
Biological Markers / analysis
Food Hypersensitivity / diagnosis*,  immunology,  therapy
Immunoglobulin E / analysis,  immunology*
Immunologic Tests*
Intradermal Tests
Predictive Value of Tests
Grant Support
Reg. No./Substance:
0/Allergens; 0/Biological Markers; 37341-29-0/Immunoglobulin E

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