| Diagnostic methods in the detection of prostate cancer: a study of a randomly selected population of 2,400 men. | |
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MedLine Citation:
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PMID: 1279225 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the value of digital rectal examination, transrectal ultrasonography and prostatic specific antigen (PSA) analysis as aids in general clinical practice and in the early detection of prostate cancer. Of a randomly selected population of 2,400 men 55 to 70 years old who were offered examination with digital rectal examination, transrectal ultrasound and PSA analysis, 1,782 (74%) accepted and prostate cancer was detected in 65 (3.6%). When the transrectal ultrasound results were also considered the detection rate of digital rectal examination (2.3%) was increased by 50% and the number of stage T2A or less tumors was doubled. At reexamination due to markedly high PSA values (7 micrograms/l. or more) only a few additional cancers (5%) were detected. However, it is noteworthy that 80% of the detected cancers were found among the subgroup with abnormal PSA values (4 micrograms/l. or more) and comprising 17% of the study population, which suggests the possibility of selecting a risk group at mass screening. Moreover, the positive predictive value increased from 4% (when only digital rectal examination was positive) to 71% for the combination of positive digital rectal examination, positive transrectal ultrasound and an increased PSA concentration (that is 7 micrograms/l. or greater). |
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Authors:
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O Gustafsson; U Norming; L E Almgård; A Fredriksson; G Gustavsson; B Harvig; C R Nyman |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of urology Volume: 148 ISSN: 0022-5347 ISO Abbreviation: J. Urol. Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1992-12-23 Completed Date: 1992-12-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1827-31 Citation Subset: AIM; IM |
Affiliation:
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Department of Urology, South Hospital, Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biopsy Evaluation Studies as Topic Humans Male Middle Aged Palpation Predictive Value of Tests Prostate-Specific Antigen / blood Prostatic Neoplasms / blood, diagnosis* Random Allocation Rectum Tumor Markers, Biological / blood Ultrasonography / methods |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological; EC 3.4.21.77/Prostate-Specific Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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