Document Detail


Diagnostic methods in the detection of prostate cancer: a study of a randomly selected population of 2,400 men.
MedLine Citation:
PMID:  1279225     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the value of digital rectal examination, transrectal ultrasonography and prostatic specific antigen (PSA) analysis as aids in general clinical practice and in the early detection of prostate cancer. Of a randomly selected population of 2,400 men 55 to 70 years old who were offered examination with digital rectal examination, transrectal ultrasound and PSA analysis, 1,782 (74%) accepted and prostate cancer was detected in 65 (3.6%). When the transrectal ultrasound results were also considered the detection rate of digital rectal examination (2.3%) was increased by 50% and the number of stage T2A or less tumors was doubled. At reexamination due to markedly high PSA values (7 micrograms/l. or more) only a few additional cancers (5%) were detected. However, it is noteworthy that 80% of the detected cancers were found among the subgroup with abnormal PSA values (4 micrograms/l. or more) and comprising 17% of the study population, which suggests the possibility of selecting a risk group at mass screening. Moreover, the positive predictive value increased from 4% (when only digital rectal examination was positive) to 71% for the combination of positive digital rectal examination, positive transrectal ultrasound and an increased PSA concentration (that is 7 micrograms/l. or greater).
Authors:
O Gustafsson; U Norming; L E Almgård; A Fredriksson; G Gustavsson; B Harvig; C R Nyman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of urology     Volume:  148     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1992-12-23     Completed Date:  1992-12-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1827-31     Citation Subset:  AIM; IM    
Affiliation:
Department of Urology, South Hospital, Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Aged
Biopsy
Evaluation Studies as Topic
Humans
Male
Middle Aged
Palpation
Predictive Value of Tests
Prostate-Specific Antigen / blood
Prostatic Neoplasms / blood,  diagnosis*
Random Allocation
Rectum
Tumor Markers, Biological / blood
Ultrasonography / methods
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological; EC 3.4.21.77/Prostate-Specific Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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